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The Genasense 'learning curve'

Nature Biotechnology volume 25, pages 972–973 (2007)Cite this article

To the editor:

I have been involved in the field of antisense therapeutics for 20 years and find the views presented in the May issue by Carol Potera in her article “Antisense—down but not out”1 to be both misleading and significantly inaccurate, especially concerning Genta's (Berkeley Heights, NJ, USA) phosphorothioate antisense compound Genasense (oblimersen sodium).

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References

  1. Potera, C. Nat Biotechnol. 25, 497–499 (2007).

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  2. O'Brien S. et al. J. Clin. Oncol. 25, 1114–1120 (2007).

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  3. Bedikian, A.Y. et al. J. Clin Oncol. 24, 4738–4745 (2006).

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Authors and Affiliations

  1. Medicine Urology and Molecular Pharmacology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, 10467, NY, USA

    C. A. Stein

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  1. C. A. Stein
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Competing interests

The author is one of a number of holders of the original NIH phosphorothioate oligonucleotide patent that was licensed by Genta and others. If Genasense is approved for marketing, he will receive a capped royalty.

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Stein, C. The Genasense 'learning curve'. Nat Biotechnol 25, 972–973 (2007). https://doi.org/10.1038/nbt0907-972

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