Nature 433, 633–638 (2005)
We reported a universal trend of amino-acid gain and loss observed for recent evolutionary history among a diverse set of 15 taxa, with amino acids of declining frequencies being the first to be incorporated into the genetic code and those of increasing frequencies being late recruits. We have since discovered that a similar scenario for protein evolution was proposed by Zuckerkandl and colleagues more than thirty years ago1. Their analysis of a far smaller vertebrate-specific data set of two protein families also revealed asymmetric patterns of amino-acid substitution, and they went on to speculate that “extrapolation to zero occurrence of the rare amino acids might define the time at which they were introduced into the genetic code.”
References
Zuckerkandl, E., Derancourt, J. & Vogel, H. Mutational trends and random processes in the evolution of informational macromolecules. J. Mol. Biol. 59, 473–490 (1971)
Additional information
The online version of the original article can be found at 10.1038/nature03306
Rights and permissions
About this article
Cite this article
Jordan, I., Kondrashov, F., Adzhubei, I. et al. Erratum: A universal trend of amino acid gain and loss in protein evolution. Nature 435, 528 (2005). https://doi.org/10.1038/nature03656
Issue Date:
DOI: https://doi.org/10.1038/nature03656
This article is cited by
-
An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein
European Biophysics Journal (2023)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.