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A highly specific pattern of volumetric brain changes due to 22q11.2 deletions in both mice and humans

Molecular Psychiatry volume 19, page 6 (2014)Cite this article

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Image highlights brain regions where similar volumetric changes occur in the Df(16)A+/− mouse model of the 22q11.2 microdeletion (a) and human subjects who harbor 22q11.2 microdeletions (b), confirming the strong face validity of the Df(16)A+/− mouse model in recapitulating 22q11.2-associated neuroanatomical changes. For more information on this topic, please refer to the article by Ellegood et al. on pages 99–107.

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Authors and Affiliations

  1. Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada

    J Ellegood, J P Lerch, P E Steadman & R M Henkelman

  2. Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA

    S Markx, M Karayiorgou & J A Gogos

  3. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    J P Lerch, P E Steadman & R M Henkelman

  4. Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands

    C Genç & S A Kushner

  5. Department of Biomedical Engineering, College of Physicians and Surgeons, Columbia University, New York, New York, USA

    F Provenzano

  6. These authors contributed equally to this work.,

    J Ellegood & S Markx

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  1. J Ellegood
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  2. S Markx
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  3. J P Lerch
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  4. P E Steadman
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  5. C Genç
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  6. F Provenzano
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  7. S A Kushner
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  8. R M Henkelman
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  9. M Karayiorgou
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  10. J A Gogos
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Ellegood, J., Markx, S., Lerch, J. et al. A highly specific pattern of volumetric brain changes due to 22q11.2 deletions in both mice and humans. Mol Psychiatry 19, 6 (2014). https://doi.org/10.1038/mp.2013.179

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