Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

The diacylglycerol kinase eta gene and bipolar disorder: a replication study in a Sardinian sample

Molecular Psychiatry volume 14, pages 350–351 (2009)Cite this article

Diacylglycerol kinase eta (DGKH) is a key enzyme involved in the regulation of the phosphatidyl inositol pathway.1 DGKH is located in 13q14, a region in linkage with bipolar disorder (BD).2 A genomewide association study (GWAS) published in this journal reported strong association between three single nucleotide polymorphisms (SNPs) located in the first intron of DGKH and bipolar disorder I (BDI) in two independent samples.3 In the attempt to replicate previous findings, we carried out an association study among the three DGKH SNPs and BD in our Sardinian sample of bipolar I patients. Moreover, as a group of patients was characterized for the response to lithium prophylaxis, we tested whether DGKH variants were involved in lithium response.

We genotyped SNPs rs9315885, rs1012053 and rs1170191 in a sample consisting of 197 BDI patients (mean age 43.0±14.8 years; mean age at onset 26.2±10.9 years; 85 men and 112 women) ascertained through the Research Diagnostic Criteria and 300 healthy controls (mean age 42±12 years; 144 men and 155 women). Response to lithium was assessed using the scale developed by Grof et al.4 Briefly, the scale measures the degree of improvement in the course of the treatment (criterion A) and weighs clinical factors considered relevant in determining whether the improvement observed is due to the lithium treatment (criteria B1–B5). The total score (TS), obtained by subtracting score B from score A, allows us to identify the phenotype of the full response to lithium therapy (TS⩾7=full responders; TS⩽0.6=others). A total of 91 patients out of 197 were eligible for the study (mean age 46.9±15.0 years; mean age at onset 27.7±11.5 years; 32 men and 59 women). Detailed assessment methods and inclusion criteria for both the case–control and the lithium response samples have been previously described.5, 6

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. van Blitterswijk WJ, Houssa B . Chem Phys Lipids 1999; 98: 95–108.

    Article  CAS  Google Scholar 

  2. Detera-Wadleigh SD, McMahon FJ . Biol Psychiatry 2006; 60: 106–114.

    Article  CAS  Google Scholar 

  3. Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B et al. Mol Psychiatry 2008; 13: 197–207.

    Article  CAS  Google Scholar 

  4. Grof P, Duffy A, Cavazzoni P, Grof E, Garnham J, MacDougall M et al. J Clin Psychiatry 2002; 63: 942–947.

    Article  CAS  Google Scholar 

  5. Manchia M, Lampus S, Chillotti C, Sardu C, Ardau R, Severino G et al. Bipolar Disord 2008; 10: 443–446.

    Article  Google Scholar 

  6. Squassina A, Congiu D, Manconi F, Manchia M, Chillotti C, Lampus S et al. Pharmacol Res 2008; 57: 369–373.

    Article  CAS  Google Scholar 

  7. Barrett JC, Fry B, Maller J, Daly MJ . Bioinformatics 2005; 21: 263–265.

    Article  CAS  Google Scholar 

  8. Wellcome Trust Case Control Consortium. Nature 2007; 447: 661–678.

    Article  Google Scholar 

  9. Baum AE, Hamshere M, Green E, Cichon S, Rietschel M, Noethen MM et al. Mol Psychiatry 2008; 13: 466–467.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neuroscience BB Brodie, University of Cagliari, Cagliari, Italy

    A Squassina, M Manchia, D Congiu, G Severino, C Chillotti, R Ardau, M Piccardi & M D Zompo

Authors
  1. A Squassina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Manchia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D Congiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G Severino
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C Chillotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R Ardau
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Piccardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M D Zompo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Squassina.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Squassina, A., Manchia, M., Congiu, D. et al. The diacylglycerol kinase eta gene and bipolar disorder: a replication study in a Sardinian sample. Mol Psychiatry 14, 350–351 (2009). https://doi.org/10.1038/mp.2008.93

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/mp.2008.93

This article is cited by

Search

Advanced search

Quick links