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Interacting effect of genetic variants of angiotensin II type 1 receptor on susceptibility to essential hypertension in Northern Han Chinese

Journal of Human Hypertension volume 23, pages 68–71 (2009)Cite this article

Best evaluated regarding the genetic makeup of human essential hypertension is the renin–angiotensin cascade, which has drawn special attention for its pivotal role in the homoeostasis of circulatory system. The major biologically active product of this cascade is angiotensin II, which is an important effector on electrolyte balance and vascular remodeling mainly by interacting with angiotensin II type 1 receptor (AT 1 R). 1

The human AT1R gene (gene: AT1R; protein: AT1R) consists of five exons and spans over 55 kb on chromosome 3q21-25. A series of biological and clinical studies have implicated AT1R as a logical candidate for involvement in the underlying cause of hypertension. The AT1R antagonists were shown to be effective anti-hypertensive agents.2 A genome-wide scan suggested that the AT1R variation was the most significant contributor to hypertension in Finnish populations.3 So far, of more than 50 polymorphisms in AT1R, 1 transversion polymorphism (A1166C) in 3′-untranslated region ranks high in relation to cardiovascular disease.4 As this silent polymorphism does not alter a potential messenger (m)RNA polyadenylation or destabilization signal,1 it does not seem to be functional, suggesting it may link with an unknown genetic variant in an important functional region of AT1R. To generate more information, we genotyped eight well-characterized promoter polymorphisms5 of AT1R along with A1166C to explore the interacting information both as haplotypes and synergistically to predict essential hypertension risk in a northern Han population. As six of these polymorphisms were found to be in complete linkage (see Supplementary Figure 2), analysis of four (G-2228A, C-1424G, C-521T and A1166C) should provide information for all possible haplotypes and interactions.

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Acknowledgements

Our work was supported by the Foundation for University Key Teacher by the Heilongjiang Ministry of Education and the Science and Technology Key Project of Heilongjiang (Grant No. G98L 19-22).

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Author notes

  1. W-Q Niu and H-Y Zhao: These authors contributed equally to this work.

Authors and Affiliations

  1. Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai, China

    W-Q Niu

  2. Department of Physiology, Qiqihar Medical College, Qiqihar, China

    H-Y Zhao & B Wang

  3. Central Laboratory, Qiqihar Medical College, Qiqihar, China

    L Zhou

  4. Department of Nephrology, Third Hospital of Qiqihar, Qiqihar, China

    X-X Dai

  5. Occupational Disease Department, Yizhong Group Hospital for Staff and Workers, Qiqihar, China

    D-Y Wang

  6. Department of Property Theory and Complication Science of Materia Medica, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China

    J Cao

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  1. W-Q Niu
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Correspondence to W-Q Niu or B Wang.

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Supplementary Information accompanies the paper on the Journal of Human Hypertension website (http://www.nature.com/jhh)

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Niu, WQ., Zhao, HY., Zhou, L. et al. Interacting effect of genetic variants of angiotensin II type 1 receptor on susceptibility to essential hypertension in Northern Han Chinese. J Hum Hypertens 23, 68–71 (2009). https://doi.org/10.1038/jhh.2008.77

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