Summary
Genetic polymorphisms of human serum orosomucoid ORM1 and ORM2 gene loci were investigated in a Libyan population sample from Tripoli, n=110, using isoelectric focusing in ultrathin layer polyacrylamide gel containing either Triton X-100 orN-(2-acetamido)-2-aminoethanesulfonic acid (ACES) with subsequent immunofixation. In ORM1 locus, six common phenotypes ORM1 1-1, ORM1 2-1, ORM1 2-2, ORM1 2.1-1, ORM1 2.1-2 and ORM1 3-1 were identified, with allele frequencies as follows:ORM1 *1=0.6500,ORM1 *2=0.3091,ORM1 *2.1=0.0318 andORM1 *3=0.0091. In ORM2 locus, one common phenotype ORM2 1 and four new heterozygote types represent products of three new variant alleles tentatively designatedORM2 * Tripoli 1, ORM2* Tripoli 2 andORM2 * Tripoli 3 were observed. In addition, one subject in which no ORM2 was detectable, the phenotype ORM2 0-0 is suggested. The ORM2 allele frequencies wereORM2 *1=0.9816,ORM2 * Tripoli 1=0.0092,ORM2 * Tripoli 2=0.0046 andORM2 * Tripoli 3=0.0046.
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Sebetan, I.M., Sagisaka, K. Genetic polymorphisms of orosomucoid ORM1 and ORM2 in libyans: Occurrence ofORM1 *2.1 and three new ORM2 alleles. Jap J Human Genet 33, 439–443 (1988). https://doi.org/10.1007/BF01897784
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DOI: https://doi.org/10.1007/BF01897784
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