Summary
Genetic polymorphism ofS-formylglutathione hydrolase (FGH) was investigated in a total of 581 red blood cell samples from unrelated Japanese using the starch gel electrophoresis and the enzyme-activity staining procedure. Three common phenotypes, FGH 1, FGH 2-1, and FGH 2, determined by two alleles,FGH*1 andFGH*2, were observed. The gene frequencies ofFGH*1 andFGH*2 in Japanese were estimated to be 0.67 and 0.33, respectively. The gene frequencies were different from those for Japanese reported by Board and Coggan (1986).
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References
Board, P.G. and Coggan, M. 1986. Genetic heterogeneity ofS-formylglutathione hydrolase.Ann. Hum. Genet. 50: 35–39.
Uotila, L. 1973. Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases.Biochemistry 12: 3938–3947.
Uotila, L. 1984. Polymorphism of red cellS-formylglutathione hydrolase in a Finnish population.Hum. Hered. 34: 273–277.
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Akiyama, K., Abe, K. Gene frequencies ofS-formylglutathione hydrolase isozyme in a Japanese population. Jap J Human Genet 31, 353–356 (1986). https://doi.org/10.1007/BF01907935
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DOI: https://doi.org/10.1007/BF01907935