Summary
Indians appeared in Malaysia early in its history. Sustained contacts often resulted in racial admixture. We have analyzed the biochemical genetic markers phosphohexose isomerase (PHI), lactate dehydrogenase (LDH), adenylate kinase (AK), hemoglobin, rhesus blood group and haptoglobin (Hp) among Malays (the indigenous people of Peninsula Malaysia) and Indians to provide genetic evidence for racial admixture of these two groups. The occurrence of specific rare variants PHI 3-1, LDH Calcutta-1 and Madras-1, and Hb S, as well as the gene frequencies of adenylate kinase and haptoglobin in Malays and Indians confirm the gene flow from Indians to Malays.
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Ananthakrishnan, R., Blake, N.M., Kirk, R.L., and Baxi, A.J. 1970. Further studies on the distribution of genetic variants of lactate dehydrogenase in India.Med. J. Aust. 2: 787–789.
Ananthakrishnan, R. and Kirk, R.L. 1969. The distribution of some serum protein and enzyme group systems in two endogamous groups in S. India.Indian J. Med. Res. 57: 1011–1017.
Arasaratnam, S. 1970.Indians in Malaysia and Singapore. Oxford University Press, London.
Bernstein, F. 1931. Die geographische Verteilung der Blutgruppen und ihre anthropologische Bedeutung. In:Comitato Italiano per lo Studio dei Problemi della Populazione. Instituto Poligrafico dello Stato, Rome.
Blackwell, R.Q. and Thephusdin, C. 1963. Distribution of haptoglobin among Thais.Nature 197: 503.
Blake, N.M., Kirk, R.L., and Baxi, A.J. 1970. The distribution of some enzyme group systems among Marathis and Gujaratis in Bombay.Hum. Hered. 20: 409–416.
Blake, N.M., McDermid, E.M., Kirk, R.L., Ong, Y.W., and Simons, M.J. 1973. The distribution of red cell enzyme groups among Chinese and Malays in Singapore.Singapore Med. J. 14: 2–8.
Bowman, J.E., Carson, P.E., Frischer, H., Powell, R.D., Colwell, E.J., Legters, L.J., Cottingham, A.J., Boone, S.C., and Hiser, W.W. 1971. Hemoglobin and red cell enzyme variation in some populations of the Republic of Vietnam with comments on the malaria hypothesis.Am. J. Phys. Anthropol 34: 313–324.
Cavalli-Sforza, L.L. and Bodmer, W.F. 1971.The Genetics of Human Populations. W.H. Freeman, San Francisco.
Chan, K.L. 1971. Human red cell adenylate kinase polymorphism in West Malaysian populations.Hum. Hered. 21: 173–179.
Chaudhuri, S., Mukherjee, B.N., Ghosh, J., and Roychoudhury, A.K. 1967. Blood groups of the Chinese in Calcutta.Nature 213: 1245.
Das, S.R., Mukherjee, B.N., Das, S.K., Ananthakrishnan, R., Blake, N.M., and Kirk, R.L. 1970. LDH variants in India.Humangenetik 9: 107–109.
Detter, J.C., Ways, P.O., Giblett, E.R., Baughan, M.A., Hopkinson, D.A., Povey, S., and Harris, H. 1968. Inherited variations in human phosphohexose isomerase.Ann. Hum. Genet. 31: 329–338.
Dewey, W.J. and Mann, J.D. 1967. Xg blood group frequencies in some further populations.J. Med. Genet. 4: 12–15.
Fildes, R.A. and Harris, H. 1966. Genetically determined variation of adenylate kinase in man.Nature 209: 261–263.
Ganesan, J. 1974.In: Annual Report. Institute for Medical Research, Kuala Lumpur, Malaysia.
Ganesan, J. 1976.In: Annual Report. Institute for Medical Research, Kuala Lumpur, Malaysia.
Giblett, E.R. and Scott, N. 1969.In: Genetic Markers in Human Blood, E.R. Giblett, ed., Blackwell Scientific Publications, Oxford.
Harris, H. and Hopkinson, D.A. 1972. Average heterozygosity per locus in man: An estimate based on the incidence of enzyme polymorphisms.Ann. Hum. Genet. 36: 9–20.
Harris, H., Hopkinson, D.A., and Robson, E.B. 1973. The incidence of rare alleles determining electrophoretic variants: Data on 43 enzyme loci in man.Ann. Hum. Genet. 37: 237–253.
Hawkins, B.R. 1974. The distribution of blood genetic markers in the Malay populations of the Malay Peninsula.Singapore Med. J. 15: 118–127.
Kirk, R.L. 1975. Isozyme variants as markers of population movement in man.In: Isozymes IV. Genetics and Evolution, C.L. Markert, ed., Academic Press, New York.
Kirk, R.L. and Lai, L.Y.C. 1962. The distribution of haptoglobin and transferrin groups in South and Southeast Asia.Acta Genet. Stat. Med. 11: 97–105.
Kirk, R.L., Lai, L.Y.C., Mahmood, S., and Singh, R.B. 1960. Haptoglobin types in South-East Asia.Nature 185: 185–186.
Kirk, R.L., Lai, L.Y.C., Vos, G.H., Wickremasinghe, R.L. and Perera, D.J.B. 1962. The blood and serum groups of selected populations in South India and Ceylon.Am. J. Phys. Anthropol. 20: 485–497.
Lie-Injo, L.E., Kosasih, E.N., and Tann, G. 1974. Variation of several erythrocyte enzymes and serum proteins of Indonesians from North Sumatra.Humangenetik 22: 331–334.
Lie-Injo, L.E., Lopez, C.G., and Ganesan, J. 1973. Lactic dehydrogenase variants in different racial groups in Malaysia.Hum. Hered. 23: 487–491.
Lie-Injo, L.E., Poey-Oey, H.G., and Mossberger, R.J. 1968. Haptoglobins, transferrins and hemoglobin B2 in Indonesians.Am. J. Hum. Genet. 20: 470–473.
Lie-Injo, L.E. and Welch, Q.B. 1972. Electrophoretic variants of 6-phosphogluconate dehydrogenase (6PGD) and phosphohexose isomerase (PHI) in different racial groups in Malaysia.Hum. Hered. 22: 338–343.
Lopez, C.G. 1966.In: Annual Report. Institute for Medical Research, Kuala Lumpur, Malaysia.
Lopez, C.G. 1971.In: Annual Report. Institute for Medical Research, Kuala Lumpur, Malaysia.
Lopez, C.G. and Lie-Injo, L.E. 1969. Hereditary haemolytic anaemias in West Malaysia.Med. J. Malaya 24: 101–106.
Maruna, R.F.L. 1959. Blutgruppen- und Rhesusfaktoren-Häufigkeit bei Indonesiern.Blut 5: 41–42.
Mourant, A.E., Beckman, L., Beckman, G., Nilsson, L.O., and Tills, D. 1968. Erythrocyte lactic dehydrogenase variants in the Icelandic and Swedish populations.Acta Genet. 18: 553–555.
Mondovano, J.A. and Gaensslen, R.E. 1975. Distribution of adenylate kinase and phosphoglucomutase isoenzyme in the population of the city of New York.Hum. Hered. 25: 488–492.
Mya-Tu, M., May-May-Yi, and Thin-Thin-Hliang. 1971. Blood groups of the Burmese population.Hum. Hered. 21: 420–430.
Omoto, K. and Blake, N.M. 1972. Distribution of genetic variants of erythrocyte phosphoglycerate kinase (PGK) and phosphohexose isomerase (PHI) among some population groups in south-east Asia and Oceania.Ann. Hum. Genet. 36: 61–67.
Omoto, K. and Harada, S. 1970. Frequencies of polymorphic types of four red cell enzymes in a central Japanese population.Jap. J. Human Genet. 14: 298–305.
Rapley, S., Robson, E.B., Harris, H., and Smith, S.M. 1967. Data on the incidence, segregation and linkage relations of the adenylate kinase (AK) polymorphism.Ann. Hum. Genet. 31: 237–242.
Saha, N. and Banerjee, B. 1973. Haemoglobinopathies in the Indian subcontinent.Acta Genet. Med. Gemellol. 22: 117–138.
Saha, N., Kirk, R.L., Shanbhag, S., Joshi, S.R., and Bhatia, H.M. 1976. Population genetic studies in Kerala and the Nilgiris (south west India).Hum. Hered. 26: 175–197.
Sanghvi, L.D. 1954. Genetic diversity in the people of western India.Eugen. Q. 1: 235–239.
Sen, N.N., Mukherjee, C.L., and Aikat, B.K. 1959. Incidence of ABO and Rh(D) blood group amongst Bengalees.J. Indian Med. Assoc. 33: 210–213.
Simmons, R.T. and Graydon, J.J. 1951. A comparison of the blood groups, subgroups, M-N and Rh types found in Java with those found in other parts of Indonesia, together with a summary of the evidence for north-south gradients in the values for the blood genesq, m, andR 1.Med. J. Aust. 1: 173–179.
Shih, L.-Y. and Hsia, D.Y.-Y. 1969. The distribution of genetic polymorphisms among Chinese in Taiwan.Hum. Hered. 19: 227–233.
Shih, L.-Y., Hsia, D.Y.-Y., Bowman, J.E., Shih, P.-L., and Shih, P.-L. 1968. The electrophoretic phenotypes of red cell 6-phosphogluconate dehydrogenase and adenylate kinase in Chinese populations.Am. J. Hum. Genet. 20: 474–477.
Steinberg, A.G., Lai, L.Y.C., Vos, G.H., Singh, R.B., and Lim, T.W. 1961. Genetic and population studies of the blood types and serum factors among Indians and Chinese from Malaya.Am. J. Hum. Genet. 13: 355–371.
Sutarman 1951. Indonesia Red Cross Society Transfusion Service (a review)., Stencilled, Djakarta.
Vella, F. and Hart, P.L.V. 1959. Sickle cell anemia in an Indian family in Malaya.Med. J. Malaya 14: 144–150.
Vesell, E.S. 1965. Genetic control of isozyme patterns in human tissues.In: Progress in Medical Genetics. Vol. 4, A.G. Steinberg and A.G. Bearn, eds., Grune and Stratton, New York, pp. 128–175.
Welch, Q.B., Lie-Injo, L.E., and Bolton, J.M. 1971. Adenylate kinase and malate dehydrogenase in four Malaysian racial groups.Humangenetik 14: 61–63.
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Teng, Y.S., Tan, S.G. Genetic evidence of gene flow from Indians to Malays. Jap J Human Genet 24, 1–8 (1979). https://doi.org/10.1007/BF01890105
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DOI: https://doi.org/10.1007/BF01890105