Abstract
Two new bisorbicillinoids, named oxosorbiquinol (1) and dihydrooxosorbiquinol (2), were isolated from a deep-sea fungus, Phialocephala sp., and their structures established using spectroscopic methods. The absolute configurations of 1 and 2 were determined by their biosynthesis route and analysis of the CD spectrum. Their cytotoxic effects on P388, A-549, HL60, BEL7402 and K562 cell lines were examined by the MTT method.
Similar content being viewed by others
Article PDF
References
Bringmanna G, Lang G, Gulder TAM, Tsuruta H, Muhlbacher J, Maksimenka K, Steffens S, Schaumann K, Stohr R, Wiese J, Imhoff JF, Perovic-Ottstadt S, Boreiko O, Muller WEG . The first sorbicillinoid alkaloids, the antileukemic sorbicillactones A and B, from a sponge-derived Penicillium chrysogenum strain. Tetrahedron 61: 7252–7265 ( 2005)
Liu WZ, Gu QQ, Zhu WM, Cui CB, Fan GT . Two new benzoquinone derivatives and two new bisorbicillinoids were isolated from a marine-derived fungus Penicillium terrestre. J Antibiot 58: 441–446 ( 2005)
Mossman T . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55–63 ( 1983)
Andrade R, Ayer WA, Mebe PP . The metabolites of Trichoderma longibrachiatum. Part I. Isolation of the metabolites and the structure of trichodimerol. Can J Chem 70: 2526–2535 ( 1992)
Andrade R, Ayer WA, Trifonov LS . The metabolites of Trichoderma longibrachiatum. III. Two new tetronic acids: 5-hydroxyvertinolide and bislongiquinolide. Aust J Chem 50: 255–258 ( 1997)
Andrade R, Ayer WA, Trifonov LS . The metabolites of Trichoderma longivrachiatum. Part II. The structures of trichodermolide and sorbiquinol. Can J Chem 74: 371–379 ( 1996)
Zhao TZ . 1H-NMR, Vol. 1. Beijing University Press, Beijing, pp. 96–99 ( 1983)
Abe N, Yamamoto K, Hirota A . Novel fungal metabolites, demethylsorbicillin and oxosorbicillinol, isolated from Trichoderma sp. USP-2690. Biosci Biotechol Biochem 64 ( 3): 620–622 ( 2000)
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Li, D., Wang, F., Cai, S. et al. Two New Bisorbicillinoids Isolated from a Deep-sea Fungus, Phialocephala sp. FL30r. J Antibiot 60, 317–320 (2007). https://doi.org/10.1038/ja.2007.40
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/ja.2007.40
Keywords
This article is cited by
-
The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis
Oncogene (2018)
-
Fungal communities from the calcareous deep-sea sediments in the Southwest India Ridge revealed by Illumina sequencing technology
World Journal of Microbiology and Biotechnology (2016)
-
Secondary metabolites of a deep sea derived fungus Aspergillus versicolor CXCTD-06-6a and their bioactivity
Journal of Ocean University of China (2014)
-
Sterigmatocystins from the deep-sea-derived fungus Aspergillus versicolor
The Journal of Antibiotics (2011)
-
Culturability and Secondary Metabolite Diversity of Extreme Microbes: Expanding Contribution of Deep Sea and Deep-Sea Vent Microbes to Natural Product Discovery
Marine Biotechnology (2011)