Abstract
Urukthapelstatin A, a novel cyclic peptide, was isolated from the cultured mycelia of marine-derived Thermoactinomycetaceae bacterium Mechercharimyces asporophorigenens YM11-542. The peptide was purified by solvent extraction, silica gel chromatography, ODS flash chromatography, and finally by preparative HPLC. Urukthapelstatin A dose-dependently inhibited the growth of human lung cancer A549 cells with an IC50 value of 12 nM. Urukthapelstatin A also showed potent cytotoxic activity against a human cancer cell line panel.
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Matsuo, Y., Kanoh, K., Yamori, T. et al. Urukthapelstatin A, a Novel Cytotoxic Substance from Marine-derived Mechercharimyces asporophorigenens YM11-542. J Antibiot 60, 251–255 (2007). https://doi.org/10.1038/ja.2007.30
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DOI: https://doi.org/10.1038/ja.2007.30
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