Abstract
The novel macrolide cruentaren A was produced at levels up to 3.2 mg/liter by cultures of the myxobacterium Byssovorax cruenta. The new compound strongly inhibited the growth of yeasts and filamentous fungi and showed high cytotoxicity against L929 mouse fibroblast cells. A minor co-metabolite of cruentaren A, named cruentaren B, and identified as a six-membered lactone isomer of cruentaren A, showed only marginal cytotoxicity and no antifungal activity. Cruentaren A inhibited F0F1 mitochondrial ATP-hydrolysis in submitochondrial particles of yeasts and beef heart.
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Article No. 104 on antibiotics from gliding bacteria. Article No.103: Niggemann J, Bedorf N, Flörke U, Steinmetz H, Gerth K, Reichenbach H, Höfle G. Eur J Org Chem 2005: 5015-5018 (2005)
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Kunze, B., Steinmetz, H., Höfle, G. et al. Cruentaren, a New Antifungal Salicylate-Type Macrolide from Byssovorax cruenta (Myxobacteria) with Inhibitory Effect on Mitochondrial ATPase Activity. J Antibiot 59, 664–668 (2006). https://doi.org/10.1038/ja.2006.89
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DOI: https://doi.org/10.1038/ja.2006.89
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