Abstract
Two new human chymase inhibitors, SPF-32629A and B, were isolated from the cultured broth of Penicillium sp. SPF-32629. These structures were determined by spectroscopic methods and identified as new pyridone compounds. SPF-32629B was the carboxylated derivative of SPF-32629A. SPF-32629A and B specifically inhibited human chymase among four serine proteases tested with the IC50 of 0.25 and 0.42 µg/ml, respectively.
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Shimatani, T., Hosotani, N., Ohnishi, M. et al. SPF-32629 A and B, Novel Human Chymase Inhibitors Produced by Penicillium sp.. J Antibiot 59, 29–34 (2006). https://doi.org/10.1038/ja.2006.5
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DOI: https://doi.org/10.1038/ja.2006.5