Abstract
Cultivation of the marine-derived streptomycete isolate B8005 delivered three known antibiotics, resistomycin (1), resistoflavin (3a) and tetracenomycin (4), and a further member of the rare resistomycin class, the weakly antibiotically active 1-hydroxy-1-norresistomycin (2). From a related marine strain B4842, 1 and resistoflavin methyl ether (3b) have been isolated. The formation of 2 is of interest from a biosynthetic point of view.
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†Art. No. XXIX on Marine Bacteria. Art. XXVIII: R. P. Maskey, E. Helmke, O. Kayser, A. Maier, H. H. Fiebig, A. Busche, H. Laatsch: Anti-cancer and antibacterial trioxacarcins with high anti-plasmodial activity from a marine Streptomycete. J Antibiot 57, 771-779 (2004).
††The same compound (1-hydroxy-1-norresistomycin) which was isolated independently from different strains appears in this issue (pages 526-529).
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Kock, I., Maskey, R., Biabani, M. et al. 1-Hydroxy-1-norresistomycin and Resistoflavin Methyl Ether: New Antibiotics from Marine-derived Streptomycetes†, ††. J Antibiot 58, 530–534 (2005). https://doi.org/10.1038/ja.2005.73
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DOI: https://doi.org/10.1038/ja.2005.73
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