Abstract
New phenylfuropyridinones and related compounds, designated citridones A, B, B′ and C, were isolated along with known CJ-16,173, from the culture broth of Penicillium sp. FKI-1938 by solvent extraction, silica gel column chromatography and HPLC. Citridones (75 µM) potentiate the miconazole activity against Candida albicans, decreasing the IC50 value of miconazole from 14.5 nM to 3.5∼6.3 nM.
Similar content being viewed by others
Article PDF
References
Nishiyama Y, Yamaguchi H . Made of action of antifungal agents for treatment of systematic fungal infection. Antibiot Chemother 16: 19–26 ( 2000)
Walsh TJ, Kasai M, Francesconi A, Landsman D, Chanock SJ . New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. J Med Vet Mycol 35: 133–137 ( 1997)
Fling ME, Kopf J, Tamarkin A, Gorman JA, Smoth HA, Koltin Y . Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate. Mol Gen Genet 227: 318–329 ( 1991)
Bossdhe HV, Marichal P, Gorrens J, Bellens D, Moereels H, Janssen PAJ . Mutation in cytochrome-P-450-dependent 14α-demethylase results in decreased affinity for azole antifungals. Bio Chem Soc Trans 18: 56–59 ( 1990)
Ōmura S . Antiinfective drugs into the 21st century. Nippon Saikingaku Zasshi 54: 795–813 ( 1999) ( in Japanese)
Arai M, Tomoda H, Okuda T, Wang H, Tabata N, Masuma R, Yamaguchi Y, Ōmura S . Funicone-related compounds, potentiators of antifungal miconazole activity, prodused by Talaromyces flavus FKI-0067. J Antibiot 55: 172–180 ( 2002)
Fukuda T, Arai M, Yamaguchi Y, Masuma R, Tomoda H, Ōmura S . New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation, and biological properties. J Antibiot 57: 110–116 ( 2004)
Fukuda T, Arai M, Tomoda H, Ōmura S . New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp. FKI-1366. II. Structure elucidation. J Antibiot 57: 117–124 ( 2004)
Sakemi S, Border J, Decosta DL, Dekker KA, Hirai H, Inagaki T, Kim YJ, Kozima N, Sims JC, Sugie Y, Sugiura A, Sutcliffe JA, Tachikawa K, Truesdell SJ, Wong JW, Toshikawa N, Kozima Y . CJ-15,696 and its analogs, new furopyridine antibiotics from the fungus Cladobotryum varium: fermentation, isolation, structural elucidation, biotransformation and antibacterial activities. J Antibiot 55: 6–18 ( 2002)
Pitt JI . A Laboratory Guide to Common Penicillium Species, 3rd ed. Food Science Australia ( 2000)
Taylor HD, Knoche L, Granville WC . Color Harmony Manual 4th Ed. Container of America, Chicago ( 1958)
National Committee Clinical Laboratory Standards . Approved Standard M27-A. NCCLS Villanova PA. ( 1997)
Raper KB, Thom C, Fennel DI . A Manual of the Penicillia. The Williams & Wilkins Co., Baltimore ( 1949)
Domsch KH, Gams W, Anderson TH . Compendium of Soil Fungi, Vol. 1. Academic Press, London, pp. 541–611 ( 1993)
Fukuda T, Tomoda H, Ōmura S . Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. II. Structure elucidation. J Antibiot 58: 315–321 ( 2005)
Breinholt J, Jensen HC, Kjaer A, Olsen CE, Rassing BR, Rosendahl CN, Sotofte I . Cladobotryal: a fungal metabolite with a novel ring system. Acta Chem Scand 52 ( 5): 631–634 ( 1998)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Fukuda, T., Yamaguchi, Y., Masuma, R. et al. Citridones, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938. J Antibiot 58, 309–314 (2005). https://doi.org/10.1038/ja.2005.38
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/ja.2005.38
Keywords
This article is cited by
-
Synthesis and biological activity of Citridone A and its derivatives
The Journal of Antibiotics (2014)
-
Citrinamides, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938
The Journal of Antibiotics (2008)
-
Sespendole, a New Inhibitor of Lipid Droplet Synthesis in Macrophages, Produced by Pseudobotrytis terrestris FKA-25
The Journal of Antibiotics (2006)
-
Tensidols, New Potentiators of Antifungal Miconazole Activity, Produced by Aspergillus niger FKI-2342
The Journal of Antibiotics (2006)
-
Yaequinolones, New Insecticidal Antibiotics Produced by Penicillium sp. FKI-2140
The Journal of Antibiotics (2006)