Abstract
We have studied in Drosophila melanogaster the effects of allozyme variation at the αGpdh and Adh loci on the following fitness components: female fecundity, egg hatchability, egg-to-adult survival under near-optimal and competitive conditions, rate of development under near-optimal and competitive conditions, and mating capacity of males. Significant effects of the αGpdh locus on rate of development under competitive conditions (SS > FS> SS), and of the Adh locus on egg hatchability (FF = SS > FS) and egg-to-adult survival under competitive conditions (FF > SS = FS) were revealed. Possible natural selection mechanisms involved in the maintenance of allozyme polymorphisms at the αGpdh and Adh loci are described. These mechanisms and the fitness of In(2L)t may account for the persistence and clinal distribution of the two allozyme polymorphisms in nature.
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Alahiotis, S, and Pelecanos, M. 1980. The effect of the environmental parameters temperature and humidity upon the variability of the gene pool in Drosophila melanogaster. Genetika, 12, 209–217.
Anderson, P R. Knibb, W R, and Oakeshott, J G. 1987. Observations on the extent and temporal estability of latitudinal clines for alcohol dehydrogenase allozymes and four chromosome inversions in Drosophila melanogaster. Genetica, 75, 81–88.
Berger, E M. 1971. A temporal survey of allelic variation in natural and laboratory populations of Drosophila melanogaster. Genetics, 67, 121–136.
Briscoe, D A. Robertson, A, and Malpica, J M. 1975. Dominance at Adh locus in response of adult Drosophila melanogaster to environmental alcohol. Nature, 255, 148–149.
Cavener, D R. 1983. The response of enzyme polymorphisms to developmental rate selection in Drosophila melanogaster. Genetics, 105, 105–113.
Charles-Palabost, L. 1982. Influence du milieu sur le maintien du polymorphisme de 1′ α-glycérophosphate déshydrogénase chez Drosophila melanogaster. Arch Zool exp génerr, 122, 467–477.
Charles-Palabost, L. 1984. Le systsystéme géne-enzyme de 1-glycérophosphate déshydrogénase chez Drosophila melanogaster. Génét Sél Evol, 16, 221–238.
Cluster, P D. Marinkovic, D. Allard, R W, and Ayala, F J. 1987. Correlations between development rates, enzyme activities, ribosomal DNA spacer-length phenotypes and adaptation in Drosophila melanogaster. Proc Natl Acad Sci USA, 84, 610–614.
Corrales, E. 1982. Anélisis de la variacion génica en una poblacion natural de Drosophila melanogaster. Tesis de Licenciatura. Universidad de Oviedo.
Day, T H. Hillier, R C, and Clarke, B. 1974a. Properties of genetically polymorphic isozymes of alcohol dehydrogenase in Drosophila melanogaster. Biochem Genet, 11, 141–153.
Day, T H. Hillier, R C, and Clarke, B. 1974b. The relative quantities and catalytic activities of enzymes produced by alleles at the alcohol dehydrogenase locus in Drosophila melanogaster. Biochem Genet, 11, 155–165.
Dobzhansky, T. 1970. Genetics of the Evolutionary Process. Columbia Univ. Press, New York.
Gibson, J B. 1970. Enzyme flexibility in Drosophila melanogaster. Nature, 227, 959–960.
Gibson, J B. May, T W, and Wilks, A V. 1981. Genetic variation at the alcohol dehydrogenase locus in Drosophila melanogaster in relation to environmental variation: Ethanol levels in breeding sites and allozyme frequencies. Oecologia (Berl.), 51, 191–198.
Gibson, J B, and Wilks, A V. 1988. The alcohol dehydrogenase polymorphism of Drosophila melanogaster in relation to environmental ethanol, ethanol tolerance and alcohol dehydrogenase activity. Heredity, 60, 403–414.
Gionfriddo, M A, and Vigue, E L. 1978. Drosophila alcohol dehydrogenase frequencies and temperature. Genet Res, Camb, 31, 97–101.
Grell, E H. 1967. Electrophoretic variants of α-glycerophosphate dehydrogenase in Drosophila melanogaster. Science, 158, 1319–1320.
Grell, E H. Jacobson, K B, and Murphy, J B. 1965. Alcohol dehydrogenase in Drosophila melanogaster: Isozymes and genetic variants. Science, 149, 80–82.
Inoue, Y. Tobari, Y N. Tsuno, K, and Watanabe, T K. 1984. Association of chromosome and enzyme polymorphisms in natural and cage populations of Drosophila melanogaster. Genetics, 106, 267–277.
Izquierdo, J I. 1987. Polimorfismo aloenzimaloenzimático en los loci aGpdh y Adh en una poblacion natural asturiana de Drosophila melanogaster. Rev Biol Univ Oviedo, 5, 3–14.
Kerver, J W M, and Van Delden, N. 1985. Development of tolerance to ethanol in relation to the alcohol dehydrogenase locus in Drosophila melanogaster. I. Adult and egg-to-adult survival in relation to ADH activity. Heredity, 55, 355–367.
Knibb, W R. 1982. Chromosome inversion polymorphisms in Drosophila melanogaster II. Geographic clines and climatic associations in Australasia, North America and Asia. Genetica, 58, 213–221.
Knibb, W R. 1983. Chromosome inversion polymorphisms in Drosophila melanogaster III. Gametic disequilibria and the contributions of inversion clines to the Adh and aGpdh clines in Australasia. Genetica, 61, 139–146.
Knibb, W R. Oakeshott, J G, and Wilson, S R. 1987. Chromosome inversion polymorphisms in Drosophila melanogaster IV. Inversion and Adh allele frequency changes under selection for different development. Heredity, 59, 95–104.
Kohane, M J, and Parsons, P A. 1986. Environment-dependent fitness differences in Drosophila melanogaster: temperature, domestication and the alcohol dehydrogenase locus. Heredity, 57, 289–304.
Levine, L, and Schawrtz, N M. 1970. Laboratory Exercises in Genetics. The C. V. Mosby Company, San Louis.
Lewontin, R C. 1974. The Genetic Basis of Evolutionary Change. Columbia Univ. Press, New York.
Malpica, J M, and Vassallo, J M. 1980. A test of the selective origin of environmentally correlated allozyme patterns. Nature, 286, 407–408.
Marinkovic, D, and Ayala, F J. 1975a. Fitness of allozyme variants in Drosophila pseudoobscura. I. Selection at the Pgm-l and Me- 2 loci. Genetics, 79, 85–95.
Marinkovic, D, and Ayala, F J. 1975b. Fitness of allozyme variants in Drosophila pseudoobscura. II. Selection at the Est-5, Odh and Mdh- 2 loci. Genet Res, Camb, 24, 137–149.
McKechnie, S W. Kohane, M, and Phillips, S C. 1981. A search for interacting polymorphic enzyme loci in Drosophila melanogaster. In Gibson, J. B. and Oakeshott, J. G. (eds) Genetic Studies of Drosophila Populations, Australian Natl. Univ., Canberra.
McKenzie, J A, and McKechnie, E W. 1978. Ethanol tolerance and the Adh polymorphism in a natural population of Drosophila melanogaster. Nature, 272, 75–76.
McKenzie, J A, and Parsons, P A. 1974. Microdifferentiation in a natural population of Drosophila melanogaster to alcohol in the environment. Genetics, 77, 385–394.
Miller, S. Pearcy, R V, and Berger, E. 1975. Polymorphism at the α-glycerophosphate dehydrogenase locus in Drosophila melanogaster. I. properties of adult allozymes. Biochem Genet, 13, 175–178.
Morgan, P. 1975. Selection acting directly on a enzyme polymorphism. Heredity, 34, 124–127.
Nei, M. 1975. Molecular Population Genetics and Evolution. American Elsevier, New York.
Nei, M, and Li, W-H. 1975. Probability or identical monomorphism in related species. Genet Res, 26, 31–43.
Nei, M, and Li, I-H. 1980. Non-random association between electromorphs and inversion chromosomes in finite populations. Genet Res, 35, 65–83.
Oakeshott, J G. 1976. Selection at the alcohol dehydrogenase locus in Drosophila melanogaster imposed by environmental ethanol. Genet Res, 26, 265–274.
Oakeshott, J G. Gibson, J B. Anderson, P R. Knibb, W R. Anderson, D G, and Chambers, G K. 1982. Alcohol dehydrogenase and glycerol-3-phosphate dehydrogenase clines in Drosophila melanogaster on different continents. Evolution, 36, 86–96.
Oakeshott, J G. Gibson, J B, and Wilson, S R. 1984a. Selective effects of the genetic background and ethanol on the alcohol dehydrogenase polymorphism in Drosophila melanogaster. Heredity, 53, 51–67.
Oakeshott, J G. McKechnie, S W, and Chambers, G K. 1984b. Population genetics of the metabolically related Adh, aGpdh and Tpi polymorphisms in Drosophila melanogaster I. Geographic variation in aGpdh and Tpi allele frequencies in different continents. Genetica, 63, 2129.
Oakeshott, J G. Wilson, S R, and Parnell, P. 1985. Selective effects of temperature on some enzyme polymorphisms in laboratory population of Drosophila melanogaster. Heredity, 55, 69–82.
O'Brien, N J, and Macintyre, R J. 1969. An analysis of gene-enzyme variability in natural populations of Drosophila melanogaster and D. Simulans. Am Nat, 103, 97–113.
Prakash, S, and Lewontin, R C. 1968. A molecular approach to the study of genie heterozygosity in natural populations. III. Direct evidence of coadaptation in gene arrangements of Drosophila. Proc Natl Acad Set USA, 59, 398–405.
Prakash, S, and Lewontin, R C. 1971. A molecular approach to the study of genie heterozygosity in natural populations. V. Further direct evidence of coadaptation in inversions of Drosophila. Genetics, 69, 405–408.
Rasmuson, B. Nilson, L R. Rasmuson, M, and Zeppezauer, E. 1966. Effects of heterozygosity on alcohol dehydrogenase (ADH) activity in Drosophila melanogaster. Hereditas, 56, 313–316.
Roca, A. Sanchez Refusta, F. Grana, C, and Comendador, M A. 1982. Chromosomal polymorphism in a population of Drosophila melanogaster. Dros Inf Serv, 58, 130–131.
Sanchez, J A. Rubio, J. Evolución del polimorfismode locienzimáticos en poblaciones experimentales deDrosophila melanogasterI. El locus alcohol des–hidrogenasa. Rev BiolUniv Oviedo, 1, 3–9.
Sanchez, J A, and Rubio, J. 1983b. Evolucion del polimorfismo de loci enzimáticos en poblaciones experimentales de Drosophila melanogaster. II. El locus a-glicerofosfato deshidrogenasa. Rev Biol Univ Oviedo, 1, 11–17.
Schenfeld, E, and McKechnie, S W. 1979. The a- glycerophosphate dehydrogenase polymorphism in Drosophila melanogaster: Adult survival under temperature stress. Theor Appl Genet, 54, 235–237.
Serradilla, J M, and Ayala, F J. 1983. Effects of allozyme variation on fitness components in Drosophila melanogaster. Genetica, 62, 139–146.
Sokal, R R, and Rohlf, F J. 1981. “Biometry”. W. H. Freeman and Company, San Francisco.
Van Delden, W. Boerema, A C, and Kamping, A. 1978. The alcohol dehydrogenase polymorphism in populations of Drosophila melanogaster. I. Selection in different environments. Genetics, 90, 161–191.
Van Delden, N, and Kamping, A. 1979. The alcohol dehydrogenase polymorphism in populations of Drosophila melanogaster III. Differences in developmental times. Genet Res, Camb, 33, 15–27.
Van Delden, N, and Kamping, A. 1983. Adaptation to alcohols in relation to the alcohol dehydrogenase locus in Drosophila melanogaster. Entomol Exp Appl 33: 97–102.
Vigue, C L, and Johnson, F M. 1973. Isozyme variability in species of the genus Drosophila. VI. Frequency-propertyenvironment relationships of allelic alcohol dehydrogenases in D. melanogaster. Biochem Genet, 9, 213–227.
Vigue, C L. Weisgram, P A, and Rosenthal, E. 1982. Selection at the alcohol dehydrogenase locus of Drosophila melanogaster: Effects of ehtanol and temperature. Bioch Genet, 20, 681–688.
Voelker, R A. Cockerham, C C. Johnson, F M. Schaffer, H E. Mukai, T, and Mettler, L E. 1978. Inversions fail to account for allozyme clines. Genetics, 88, 515–527.
Watanabe, T K, and Watanabe, T. 1977. Enzyme and chromosome polymorphisms in Japanese natural populations of Drosophila melanogaster. Genetics, 85, 319–329.
Weir, B S, and Cockerham, C C. 1979. Estimation of linkage disequilibrium in randomly mating populations. Heredity, 42, 105–111.
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Izquierdo, J., Rubio, J. Allozyme polymorphism at the αGpdh and Adh loci and fitness in Drosophila melanogaster. Heredity 63, 343–352 (1989). https://doi.org/10.1038/hdy.1989.108
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DOI: https://doi.org/10.1038/hdy.1989.108
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