Publication in top tier journals has become increasingly competitive, and the prestige of the journal is used to rank the strength and impact of scientific papers. In this overview of Nature Publishing Group, I will discuss what makes Nature titles distinct from other journals, the range of publishing options within NPG, and how the different journals within NPG interact. I will talk about the pre-submission inquiries, what happens to your paper once you submit it, the selection criteria that editors use for selecting which papers to have peer reviewed, and how editors select reviewers. I'll also provide advice from an editor's perspective on how you as an author can most effectively communicate with journal editors.