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Type 1 interferon-associated necroptosis: a novel mechanism for Salmonella enterica Typhimurium to induce macrophage death

Cellular & Molecular Immunology volume 10, pages 10–12 (2013)Cite this article

As one of the facultatively intracellular bacteria, Salmonella enterica serovar Typhimurium (S. Typhimurium) replicates even in macrophages and induces their death—a key strategy of this virulent pathogen in evading the innate immune response.1 The underlying mechanisms are well known but complex, because many pathways are involved, such as apoptosis,2 necrosis,3 pyroptosis4 and autophagy.5 In a recent issue of Nature Immunology, Robinson et al. reveal a novel pathway for killing macrophages during infection: type 1 interferon- (IFN-α and IFN-β) associated necroptosis.6

To understand the novel pathway better, it is important to clarify the major differences between necrosis, apoptosis, autophagy, necroptosis and pyroptosis, and to recognize the various roles of IFN-α or IFN-β. The four pathways of programmed cell death (apoptosis, autophagy, necroptosis and pyroptosis) are compared in Table 1.

Table 1 Comparison of four major pathways of programmed cell death
Full size table

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Figure 1

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  1. Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan

    Zhi-Qing Hu & Wei-Hua Zhao

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Hu, ZQ., Zhao, WH. Type 1 interferon-associated necroptosis: a novel mechanism for Salmonella enterica Typhimurium to induce macrophage death. Cell Mol Immunol 10, 10–12 (2013). https://doi.org/10.1038/cmi.2012.54

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