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Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments

Cellular & Molecular Immunology volume 9, pages 163–174 (2012)Cite this article

Abstract

The immune systems of wild rats and of laboratory rats can been utilized as models of the human immune system in pre-industrial and post-industrial societies, respectively. In this study, lymphocyte phenotypes in wild rats were broadly characterized, and the results were compared to those obtained by us and by others using cells derived from various strains of laboratory rats. Although not expected, the production of regulatory T cells was not apparently different in wild rats compared to laboratory rats. On the other hand, differences in expression of markers involved in complement regulation, adhesion, signaling and maturation suggest increased complement regulation and decreased sensitivity in wild-caught rats compared to laboratory rats, and point toward complex differences between the maturation of T cells. The results potentially lend insight into the pathogenesis of post-industrial epidemics of allergy and autoimmune disease.

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Acknowledgements

This work was supported in part by award AI-51445 (Duke Human Vaccine Institute Flow Cytometry Core Facility).

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Authors and Affiliations

  1. Department of Surgery, Duke University Medical Center, Durham, 27710, NC, USA

    Ashley M Trama, Zoie E Holzknecht, Anitra D Thomas, Kuei-Ying Su, Sean M Lee, Emily E Foltz, Shu S Lin & William Parker

  2. Cardiff School of Biosciences, Cardiff, CF10 3AX, UK

    Sarah E Perkins

  3. Department of Immunology, Duke University Medical Center, Durham, 27710, NC, USA

    Shu S Lin

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Trama, A., Holzknecht, Z., Thomas, A. et al. Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments. Cell Mol Immunol 9, 163–174 (2012). https://doi.org/10.1038/cmi.2011.61

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