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Aplastic Anemia

Second allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia

Bone Marrow Transplantation volume 50, pages 1312–1315 (2015)Cite this article

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Abstract

The outcome of 55 children with severe aplastic anemia (SAA) who received a second hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed using the registration data of the Japanese Society for Hematopoietic Cell Transplantation. The 5-year overall survival (OS) and failure-free survival (FFS) after the second transplantation were 82.9% (95% confidence interval (CI), 69.7–90.8)) and 81.2% (95% CI, 67.8–89.4), respectively. FFS was significantly better when the interval between the first and second transplantation was >60 days (88.9%; 95% CI, 73.0–95.7) than when it was ⩽60 days (61.4%; 95% CI, 33.3–80.5; P=0.026). All 12 patients who were conditioned with regimens containing fludarabine and melphalan were alive with hematopoietic recovery. These findings justify the recommendation of a second HSCT for children with SAA who have experienced graft failure after first HSCT.

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Acknowledgements

We thank all participating doctors and patients who were involved in the Japanese Hematopoietic Cell Transplantation Registry. This work was supported in part by a Research Grant for Allergic Disease and Immunology from the Japanese Ministry of Health, Labor and Welfare.

Author Contributions

KazK and SK designed the research, analyzed the data and wrote the manuscript. HM, NY, RK, HY, KT, KKoh, YT, YC, KeiK, YH, MI, HS, KKawa and KojiK collected and managed the clinical data and discussed the results. RS supervised the data analyses.

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Authors and Affiliations

  1. Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan

    K Kudo

  2. Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan

    H Muramatsu, Y Takahashi & S Kojima

  3. Division of Pediatric Hematology/Oncology, Children’s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

    N Yoshida & K Kato

  4. Department of Pediatrics, Sapporo Hokuyu Hospital, Sapporo, Japan

    R Kobayashi

  5. Department of Cell Transplantation and Regeneration Medicine, Tokai University School of Medicine, Isehara, Japan

    H Yabe

  6. Division of Pediatrics, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan

    K Tabuchi

  7. Division of Pediatric Hematology and Oncology, Ibaraki Children’s Hospital, Mito, Japan

    K Kato

  8. Department of Hematology and Oncology, Saitama Children's Medical Center, Saitama, Japan

    K Koh

  9. Department of Pediatrics, Osaka University Hospital, Suita, Japan

    Y Hashii

  10. Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, Japan

    Y Kawano

  11. Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan

    M Inoue

  12. Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan

    Y Cho

  13. Division of Hematology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan

    H Sakamaki

  14. Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan

    K Kawa

  15. Department of Hematopoietic Stem Cell Transplantation, Data Management and Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan

    R Suzuki

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  1. K Kudo
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  2. H Muramatsu
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  7. K Kato
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  8. K Koh
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  10. Y Hashii
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  11. Y Kawano
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  12. M Inoue
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  14. H Sakamaki
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  15. K Kawa
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  16. K Kato
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  17. R Suzuki
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  18. S Kojima
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Correspondence to K Kudo.

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Kudo, K., Muramatsu, H., Yoshida, N. et al. Second allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia. Bone Marrow Transplant 50, 1312–1315 (2015). https://doi.org/10.1038/bmt.2015.153

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  • DOI: https://doi.org/10.1038/bmt.2015.153

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