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Long-term outcomes in adult patients below the age of 55 years with acute lymphoblastic leukemia treated with chemotherapy or allogeneic BM transplant in first CR

Bone Marrow Transplantation volume 45, pages 1256–1258 (2010)Cite this article

Several studies have analyzed the role of allogeneic BMT (alloBMT) in adult patients with acute lymphoblastic leukemia (ALL) in first CR in comparison with chemotherapy and/or autologous transplant.1, 2, 3, 4 However, there are lack of information on long-term follow-up and complications in these patients. The patients treated with alloBMT or chemotherapy alone may have a different spectrum of long-term complications.

We reported earlier on the results of 92 adult patients below the age of 55 years with ALL treated at Princess Margaret Hospital from September 1992 to October 2001.2 According to the institutional policy, these patients were offered alloBMT in first CR if a related donor was available. Unrelated donor transplants were offered to Ph positive ALL (Ph+ALL) patients. Of the 87 patients achieving first CR with induction therapy, the comparison of patients with (n=48) or without donors (n=39) did not show any significant difference in leukemia-free survival or OS.

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Authors and Affiliations

  1. Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, Canada

    R Kohli, J Brandwein, M D Minden, A Schimmer, A C Schuh, J H Lipton, K Yee, H A Messner & V Gupta

  2. Department of Biostatistics, Princess Margaret Hospital, Toronto, Canada

    W Xu

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  1. R Kohli
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  2. W Xu
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  3. J Brandwein
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  4. M D Minden
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  5. A Schimmer
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  6. A C Schuh
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  7. J H Lipton
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  8. K Yee
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  9. H A Messner
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  10. V Gupta
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Correspondence to V Gupta.

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Kohli, R., Xu, W., Brandwein, J. et al. Long-term outcomes in adult patients below the age of 55 years with acute lymphoblastic leukemia treated with chemotherapy or allogeneic BM transplant in first CR. Bone Marrow Transplant 45, 1256–1258 (2010). https://doi.org/10.1038/bmt.2009.324

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