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No impact of NOD2/CARD15 on outcome after SCT: a reply

Bone Marrow Transplantation volume 42, pages 837–838 (2008)Cite this article

In a recent issue of Bone Marrow Transplantation, Dr Sairafi et al.1 reported the results of a retrospective study to investigate the impact of NOD2/CARD15 single nucleotide polymorphisms (SNPs) on the outcome of allogeneic haematopoietic stem cell transplants (HSCT). They found no significant correlation between the presence of a NOD2/CARD15 SNP and the incidence of acute GVHD, TRM, relapse-free survival or overall survival. We have recently reported the results of a retrospective analysis of the impact of NOD2/CARD15 SNPs on the outcome of 196 unrelated donor HSCT (UD-HSCT) pairs where the recipient was diagnosed with acute leukaemia. We found that the presence of a NOD2/CARD15 SNP correlated with a significant reduction in overall survival because of an increase in disease relapse.2 Numerous other studies have shown the presence of SNPs to have a detrimental effect on the outcome of HSCT although the actual complication observed varies between groups and is thought to be dependent on specific characteristics of the cohort itself.3, 4, 5, 6, 7

It would be of interest to see if Sairafi et al. were able to see an effect in more homogeneous subgroups of their cohort, particularly in the acute leukaemia recipients and the UD pairs. This study adds much to the discussion that the effects of NOD2/CARD15 polymorphisms on the outcome of HSCT are very much dependent on the combination of transplant regimen and donor source, and that interpretation and comparison of data must be thorough. In addition, it also shows that the variation of SNP frequencies in different populations can affect such studies.

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References

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Authors and Affiliations

  1. Anthony Nolan Research Institute, The Royal Free Hospital, UK

    N P Mayor, B E Shaw, J A Madrigal & S G E Marsh

  2. UCL Cancer Institute, Royal Free Campus, UK

    N P Mayor, J A Madrigal & S G E Marsh

  3. Section of Haemato-Oncology, The Royal Marsden Hospital, UK

    B E Shaw

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  1. N P Mayor
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  2. B E Shaw
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  3. J A Madrigal
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  4. S G E Marsh
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Correspondence to S G E Marsh.

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Mayor, N., Shaw, B., Madrigal, J. et al. No impact of NOD2/CARD15 on outcome after SCT: a reply. Bone Marrow Transplant 42, 837–838 (2008). https://doi.org/10.1038/bmt.2008.251

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