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Myeloablative chemotherapy with autologous stem cell rescue for Ewing sarcoma

Bone Marrow Transplantation volume 42, page 761 (2008)Cite this article

The report by Gardner et al.1 analyzes International Blood and Marrow Transplant Registry (IBMTR) data regarding myeloablative therapy with autologous stem cell rescue for Ewing sarcoma. The limitations of this report, which is based on an observational database, are reviewed in the Discussion. Clarifications about some of the comparisons in the Discussion are important because this article will likely influence clinical practice.

For example, a comparison of the outcome for patients with localized disease at diagnosis is made. The comparison is between the IBMTR results for megatherapy and the results of a study that incorporated etoposide and ifosfamide.2 The latter study was not limited to high-risk patients, so it is possible that there was a significant difference in risk factors such as tumor size and location. Because the addition of etoposide and ifosfamide was shown to improve outcome, the induction therapy used is important for this comparison and it is not known for the IBMTR patients.

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References

  1. Gardner SL, Carreras J, Boudreau C, Camitta BM, Adams RH, Chen AR et al. Myeloablative therapy with autologous stem cell rescue for patients with Ewing sarcoma. Bone Marrow Transplant 2008; 41: 867–872.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003; 348: 694–701.

    Article  CAS  PubMed  Google Scholar 

  3. Miser JS, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ et al. Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide—a Children's Cancer Group and Pediatric Oncology Group Study. J Clin Oncol 2004; 22: 2873–2876.

    Article  CAS  PubMed  Google Scholar 

  4. Oberlin O, Rey A, Desfachelles AS, Philip T, Plantaz D, Schmitt C et al. Impact of high-dose busulfan plus melphalan as consolidation in metastatic Ewing tumors: a study by the Societe Francaise des Cancers de l'Enfant. J Clin Oncol 2006; 24: 3997–4002.

    Article  CAS  PubMed  Google Scholar 

  5. Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, Ramsay NK . Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. N Engl J Med 1999; 341: 1165–1173.

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Pediatrics, Levine Children's Hospital, Charlotte, NC, USA

    A L Gilman & J Oesterheld

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  1. A L Gilman
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  2. J Oesterheld
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Correspondence to A L Gilman.

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Gilman, A., Oesterheld, J. Myeloablative chemotherapy with autologous stem cell rescue for Ewing sarcoma. Bone Marrow Transplant 42, 761 (2008). https://doi.org/10.1038/bmt.2008.240

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