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Ovarian shielding allows ovarian recovery and normal birth in female hematopoietic SCT recipients undergoing TBI

Bone Marrow Transplantation volume 42, pages 697–699 (2008)Cite this article

A Corrigendum to this article was published on 24 December 2008

Hematopoietic SCT is an established treatment for a variety of hematological malignancies.1 However, the antitumor effect relies partly on the conditioning regimen before transplantation, which is performed with high-dose chemotherapy with or without the use of TBI, a regimen that causes severe toxicity to the ovaries.2 Successful pregnancies following TBI of more than 10 Gy have been reported, but they are extremely rare.3, 4, 5 The aim of this study was to preserve ovarian function by ovarian shielding while undergoing TBI for hematopoietic SCT.6

The subjects in this study were women under 40 years of age, who were undergoing allogeneic hematopoietic SCT, using a TBI-based regimen, and who desired to have children after transplantation. The study was approved by the Ethics committee of the University of Tokyo Hospital and all patients gave informed consent to participate in this study.

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Authors and Affiliations

  1. Department of Radiology, University of Tokyo Hospital, Tokyo, Japan

    K Nakagawa, H Yamashita, N Sasano & K Ohtomo

  2. Department of Hematology, Saitama Medical Center, Jichi Medical School, Tochigi, Japan

    Y Kanda

  3. Department of Obstetrics and Gynecology, University of Tokyo Hospital, Tokyo, Japan

    S Nakagawa

  4. Department of Hematology and Oncology, University of Tokyo Hospital, Tokyo, Japan

    K Oshima, K Kumano, Y Minamitani & M Kurokawa

  5. Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, Japan

    N Ban

  6. Department of Cell Therapy & Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan

    S Chiba

Authors
  1. K Nakagawa
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  2. Y Kanda
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  3. H Yamashita
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  4. S Nakagawa
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  5. N Sasano
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  6. K Ohtomo
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  7. K Oshima
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  8. K Kumano
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  9. N Ban
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  10. Y Minamitani
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  11. M Kurokawa
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  12. S Chiba
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Corresponding author

Correspondence to H Yamashita.

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Nakagawa, K., Kanda, Y., Yamashita, H. et al. Ovarian shielding allows ovarian recovery and normal birth in female hematopoietic SCT recipients undergoing TBI. Bone Marrow Transplant 42, 697–699 (2008). https://doi.org/10.1038/bmt.2008.234

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