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  • Clinical Oncology/Epidemiology
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Clinical Oncology/Epidemiology

Phase II trials of rhizoxin in advanced ovarian, colorectal and renal cancer

British Journal of Cancer volume 72, pages 1267–1269 (1995)Cite this article

Abstract

Rhizoxin is a tubulin-binding anti-neoplastic agent which is active in a range of murine tumour models. The recommended schedule, of intravenous (i.v.) bolus administration at a dose of 2 mg m-2 every 3 weeks, has been assessed in three phase II trials of ovarian, renal and colorectal cancer. In general terms the drug was fairly well tolerated, but the response rate was disappointing: 0/18, colorectal cancer; 0/18, renal cancer; 1 partial response (PR)/17, ovarian cancer.

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Authors and Affiliations

  1. University of Birmingham CRC Institute for Cancer Studies, Queen Elizabeth Hospital, UK

    DJ Kerr

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  1. DJ Kerr
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  2. GJ Rustin
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  3. SB Kaye
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  4. P Selby
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  5. NM Bleehen
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  6. P Harper
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  7. MH Brampton
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Kerr, D., Rustin, G., Kaye, S. et al. Phase II trials of rhizoxin in advanced ovarian, colorectal and renal cancer. Br J Cancer 72, 1267–1269 (1995). https://doi.org/10.1038/bjc.1995.498

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  • DOI: https://doi.org/10.1038/bjc.1995.498

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