Abstract
A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.
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Burns, J., Lemoine, L., Lemoine, N. et al. Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T. Br J Cancer 59, 755–760 (1989). https://doi.org/10.1038/bjc.1989.158
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DOI: https://doi.org/10.1038/bjc.1989.158
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