Abstract
The x-ray dose required to cure half the mice bearing first generation transplanted mammary carcinomata 150 days after irradiation was determined. NDPP proved to be a relatively poor radiosensitizer in mice, for although a maximum enhancement ratio of 1-3 was obtained when x-rays produced from a 1-4 MeVp electron accelerator were given between 10 and 17 min after the administration of NDPP, this was at a drug concentration sufficient to cause marked kidney abnormalities in 5-10% of the mice.
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Sheldon, P., Smith, A. Modest radiosensitization of solid tumours in C3H mice by the hypoxic cell radiosensitizer NDPP. Br J Cancer 31, 81–88 (1975). https://doi.org/10.1038/bjc.1975.10
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DOI: https://doi.org/10.1038/bjc.1975.10
