Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perinatal/Neonatal Case Presentation
  • Published:

Perinatal/Neonatal Case Presentation

Pregnancy and active Huntington disease: a rare combination

Journal of Perinatology volume 28, pages 156–157 (2008)Cite this article

Abstract

We describe the complicated course of a rare pregnant woman with symptomatic Huntington disease (HD) and discuss multidisciplinary care issues that may be encountered. A 31-year-old gravida 2, para 1 with advanced HD was admitted at 30 weeks gestation for preterm labor. Her course was complicated by progressive cognitive and physical impairment, dysphagia, malnutrition, diabetes insipidus, aspiration pneumonia, chorioamnionitis, preterm delivery and pyelonephritis. Pregnant women with symptomatic HD may present multiple challenges requiring extensive multidisciplinary input.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bhidayasiri R, Truong DD . Chorea and related disorders. Postgrad Med J 2004; 80: 527–534.

    Article  CAS  Google Scholar 

  2. Rimion DL, Connor JM, Pyertiz RE, Korf BR (eds). Basal Ganglia Disorders. Principles and Practice of Medical Genetics. 4th edn. Churchill Livinstone Publishers: New York (NY), 2002, pp 3076–3108.

    Google Scholar 

  3. Shahine LK, Caughey AB . Preimplantation genetic diagnosis: the earliest form of prenatal diagnosis. Gynecol Obstet Invest 2005; 60: 36–46.

    Article  Google Scholar 

  4. Durr JA, Lindheimer MD . Diagnosis and management of diabetes insipidus during pregnancy. Endocr Pract 1996; 2: 353–361.

    Article  CAS  Google Scholar 

  5. Kotliarova S, Jana NR, Sakamoto N, Kurosawa M, Miyazaki H, Nekooki M et al. Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-EGFP fluorescent aggregates. J Neurochem 2005; 93: 641–653.

    Article  CAS  Google Scholar 

  6. Peterson A, Bjorkqvist M . Hypothalamic-endocrine aspects in Huntington's disease. Eur J Neurosci 2006; 24: 961–967.

    Article  Google Scholar 

Download references

Author information

Author notes

  1. J R Biggio: Supported by NIH/NICHD Grant #K12-HD001258-06

  2. P S Ramsey: Supported by NIH/NICHD Grant # K12-HD01402

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA

    K E Hoskins, A T N Tita, J R Biggio & P S Ramsey

Authors
  1. K E Hoskins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A T N Tita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J R Biggio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P S Ramsey
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K E Hoskins.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hoskins, K., Tita, A., Biggio, J. et al. Pregnancy and active Huntington disease: a rare combination. J Perinatol 28, 156–157 (2008). https://doi.org/10.1038/sj.jp.7211874

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7211874

Keywords

Search

Advanced search

Quick links