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COX inhibition for tocolysis and its effect on the neonate

Journal of Perinatology volume 27, page 395 (2007)Cite this article

This is with reference to the article ’The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants’ by Cordero et al.1 Maternal ingestion of COX inhibitors in the last trimester has been reported to cause neonatal renal failure. This is due to maturation arrest of the nephrons owing to COX 2 inhibition. More importantly, this renal failure is irreversible. One should be forewarned of this possible complication when using NSAIDs during pregnancy for any indication. In the reported series, was the renal status of the neonates evaluated?2, 3, 4, 5

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References

  1. Cordero L, Nankervis CA, Gardner D, Giannone PJ . The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants. J Perinatol 2007; 27: 22–27.

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  1. Kidney Care Center, SNH, Tirunelveli, Tamilnadu, India. E-mail: kidneycare@yahoo.com,

    J Balasubramaniam

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  1. J Balasubramaniam
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Balasubramaniam, J. COX inhibition for tocolysis and its effect on the neonate. J Perinatol 27, 395 (2007). https://doi.org/10.1038/sj.jp.7211744

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