Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Response to Dr Jeyaraj

Journal of Perinatology volume 27, page 395 (2007)Cite this article

We have read with interest the comments made by Dr Jeyaraj on cyclo-oxygenase inhibition for tocolysis and its effect on the neonate.1 We appreciate learning that nimesulide use as a tocolytic has been associated with irreversible renal failure in infants. It is comforting to know that nimesulide has not been approved for marketing in the United States, United Kingdom, Australia or Canada.2

In regard to our recent study (Cordero et al.3), we noted that serum creatinine levels from 58 premature infants exposed to antenatal indomethacin, and those from 58 control showed similar values at birth, comparable increases during the second and third day and progressive declines to baseline levels during the following 2 weeks. In our series, only two infants from each group showed significant, albeit temporary oliguria. No cases of irreversible renal failure occurred in either group of infants.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Jeyaraj B . COX inhibition for tocolysis and its effect on the neonate. Letter to the editor. J Perinatol in press.

  2. Micromedex® Healthcare. Micromedex® Healthcare Series. 2007 (intranet database). Version 5.1 Greenwood Village: Colo, USA.

  3. Cordero L, Nankervis CA, Gardner D, Giannone PJ . The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants. J Perinatol 2007; 27: 22–27.

    Article  CAS  Google Scholar 

  4. Miall LS, Henderson MJ, Turner AJ, Brownlee KG, Brocklebank T, Newell SJ et al. Plasma creatinine rises dramatically in the first 48 h of life in preterm infants. Pediatrics 1999; 104: e76.

    Article  CAS  Google Scholar 

  5. Butler-O'Hara M, D'Angio CT . Risk of persistent renal insufficiency in premature infants following the prenatal use of indomethacin for suppression of preterm labor. J Perinatol 2002; 22: 541–546.

    Article  Google Scholar 

  6. Fowlie PW, Davis PG . Prophylactic indomethacin for preterm infants; a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 2003; 88: F464–F466.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University Hospitals, Columbus, OH, USA. E-mail: leandro.cordero@osumc.edu,

    L Cordero

Authors
  1. L Cordero
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cordero, L. Response to Dr Jeyaraj. J Perinatol 27, 395 (2007). https://doi.org/10.1038/sj.jp.7211740

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7211740

Search

Advanced search

Quick links