Abstract
Congenital thyrotoxicosis is a rare and potentially fatal illness. We report a case in a preterm infant delivered to a mother known to have autoimmune endocrine disease. Diagnosis was difficult because the infant's presenting symptoms and signs closely resembled congenital viral infection with co-existent hepatic dysfunction and coagulopathy. The associated hepatic dysfunction was so severe that liver biopsy was scheduled before the diagnosis emerged. A high degree of clinical suspicion coupled with prenatal identification of pregnancies at risk of complication by congenital thyrotoxicosis is imperative to facilitate prompt diagnosis and treatment.
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Dryden, C., Simpson, J., Hunter, L. et al. An unusual cause of neonatal coagulopathy and liver disease. J Perinatol 27, 320–322 (2007). https://doi.org/10.1038/sj.jp.7211687
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DOI: https://doi.org/10.1038/sj.jp.7211687