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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Successful treatment with oral valganciclovir in immunocompetent infant with gastrointestinal manifestations of cytomegalovirus infection

Journal of Perinatology volume 26, pages 648–649 (2006)Cite this article

Abstract

A 3-month-old male infant was admitted to hospital with anemia. Follow-up controls revealed the presence of specific cytomegalovirus (CMV) antibodies. Virus was isolated from urine, blood, and saliva. At 7 months of age, he presented with melena. Polymerase chain reaction (PCR) of biopsy samples from the duodenum was positive for CMV. Anemia resolved after starting antiviral therapy with oral valganciclovir.

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References

  1. Weinstein M, Ford-Jones E, Cutz E . Esophagitis and perinatal cytomegalovirus infection. Pediatr Infect Dis J 2001; 20: 545–546.

    Article  CAS  Google Scholar 

  2. Schleiss MR . Antiviral therapy of congenital cytomegalovirus infection. Semin Pediatr Infect Dis 2005; 16: 50–59.

    Article  Google Scholar 

  3. Schleiss MR, McVoy MA . Overview of congenitally and perinatally acquired cytomegalovirus infections: recent advances in antiviral therapy. Exp Rev Anti-infective Ther 2004; 2: 389–403.

    Article  CAS  Google Scholar 

  4. Whitley RJ, Cloud G, Gruber W, Storch GA, Demonler GJ, Jacobs RF et al. Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study. J Infect Dis 1997; 175: 1080–1086.

    Article  CAS  Google Scholar 

  5. Kimberlin DW . Antiviral therapy for cytomegalovirus infections in pediatric patients. Semin Pediatr Infect Dis 2002; 13: 22–30.

    Article  Google Scholar 

  6. De Clercq E . Antiviral drugs in current clinical use. J Clin Virol 2004; 30: 115–133.

    Article  CAS  Google Scholar 

  7. Meine Jansen CF, Toet MC, Rademaker CM, Ververs TF, Gerards LJ, van Loon AM . Treatment of symptomatic congenital cytomegalovirus infection with valganciclovir. J Perinat Med 2005; 33: 364–366.

    PubMed  Google Scholar 

  8. Henkin C, Griener J, Ten Eick A . Stability of valganciclovir in extemporaneously compounded liquid formulations. Am J Health-Syst Pharm 2003; 60: 687–690.

    CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Irene Scarano, MD, and Gaetano Mauro, MD, who prepared the oral liquid formulation of valganciclovir.

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Authors and Affiliations

  1. Division of Pediatric Oncology, Department of Paediatrics, Università Cattolica del Sacro Cuore, Policlinico ‘A Gemelli’, Rome, Italy

    P S Buonuomo, P Maurizi, S Mastrangelo, I Lazzareschi, V Ridola & R Riccardi

  2. Department of Paediatrics, Pediatric Infectious Disease, Università Cattolica del Sacro Cuore, Policlinico ‘A Gemelli’, Rome, Italy

    P Valentini

Authors
  1. P S Buonuomo
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  2. P Maurizi
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  3. P Valentini
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  4. S Mastrangelo
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  5. I Lazzareschi
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  6. V Ridola
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  7. R Riccardi
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Correspondence to P S Buonuomo.

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Buonuomo, P., Maurizi, P., Valentini, P. et al. Successful treatment with oral valganciclovir in immunocompetent infant with gastrointestinal manifestations of cytomegalovirus infection. J Perinatol 26, 648–649 (2006). https://doi.org/10.1038/sj.jp.7211578

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  • DOI: https://doi.org/10.1038/sj.jp.7211578

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