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The Hemodynamic Effects of Neonatal Patent Ductus Arteriosus Shunting on Superior Mesenteric Artery Blood Flow

Journal of Perinatology volume 25, pages 459–462 (2005)Cite this article

Abstract

OBJECTIVE:

To determine if the ratio of the pulsatility index (PI) of the left pulmonary artery to the PI of the descending aorta, the Rp/Rs index, correlates with the degree of ductal steal from the intestine in neonates with a patent ductus arteriosus (PDA).

STUDY DESIGN:

Echocardiograms and Doppler studies of the superior mesenteric artery (SMA) were performed in 41 neonates less than 35 weeks gestational age with a hemodynamically significant PDA (hsPDA).

RESULTS:

There was a significant negative correlation between the Rp/Rs index and the SMA PI after controlling for ductal size (r=−0.476, p<0.008).

CONCLUSIONS:

The Rp/Rs index can be used as an indicator of ductal steal on intestinal blood flow. The Rp/Rs index may be a useful adjunct to existing and new techniques for improving early assessment and treatment of hsPDA, and for evaluating the effects of hsPDA on systemic organs.

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Acknowledgements

We acknowledge the assistance and cardiac technical support from Pamela Humiston, Judy Zaritt, Felicia Jones, James Paul, Susan Levy, Stan Timofeev, Chris Madramootoo, Mike French, Patrick Johanboeke, Greg Peters, Johanna Loaiza, and Kelli Sinclair. We also like to express great appreciation to USF Neonatology Department (Terri Ashmeade, MD, Lewis Barness, MD, Laura Haubner, MD, Robert Nelson, MD and Monisha Saste, MD) for their cooperation, support and editorial review skills.

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Authors and Affiliations

  1. Department of Pediatrics, University of South Florida College of Medicine, Tampa, FL, USA

    Mayra Freeman-Ladd MD, Jane D Carver PhD & James C Huhta MD

  2. Department of Anesthesiology, University of South Florida College of Medicine, Tampa, FL, USA

    Jonathan B Cohen MD

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  1. Mayra Freeman-Ladd MD
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  2. Jonathan B Cohen MD
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  3. Jane D Carver PhD
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  4. James C Huhta MD
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Freeman-Ladd, M., Cohen, J., Carver, J. et al. The Hemodynamic Effects of Neonatal Patent Ductus Arteriosus Shunting on Superior Mesenteric Artery Blood Flow. J Perinatol 25, 459–462 (2005). https://doi.org/10.1038/sj.jp.7211294

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