Abstract
OBJECTIVE: To evaluate serum procalcitonin concentration in umbilical cord blood for diagnosis of intrauterine bacterial infection.
MATERIALS AND METHODS: A prospective study was conducted between 2000 and 2001. Serum procalcitonin concentrations were evaluated in 187 umbilical cord blood samples. Five groups have been defined: controls A (n=37), full-term noninfected B1 (n=80) and infected neonates B2 (n=8), preterm noninfected C1 (n=38) and infected C2 (n=24) newborns. An immunoluminometric assay was used to determine procalcitonin concentration. The Mann–Whitney U-test and Spearman's correlation ratio were applied. The sensitivity and specificity, the positive and negative predictive values, and the area under receiver operating characteristic curves were calculated.
RESULTS: A statistically higher serum procalcitonin concentration was found in the preterm infected group (p<0.005; C2 vs A and C1).
CONCLUSION: Serum procalcitonin concentration in umbilical cord blood may be a useful parameter in the diagnosis of early neonatal infection.
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This work was supported by Grant KBN 4 P05E 138 19.
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Serum procalcitonin concentration in umbilical cord blood may be a useful parameter in the diagnosis of intrauterine bacterial infection in newborn infants.
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Kordek, A., Giedrys-Kalemba, S., Pawlus, B. et al. Umbilical Cord Blood Serum Procalcitonin Concentration in the Diagnosis of Early Neonatal Infection. J Perinatol 23, 148–153 (2003). https://doi.org/10.1038/sj.jp.7210885
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DOI: https://doi.org/10.1038/sj.jp.7210885
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