Sir,
Central retinal artery obstruction (CRAO) is uncommon in young adults, the mean age being 60 years. Emboli are visible in 25% of cases and embolic sources found in 40% of patients.1 We present the case of young man with visual loss due to a central retinal artery occlusion secondary to a patent foramen ovale (PFO).
Case report
A 22-year-old male student was referred to the Southampton Eye Unit with sudden visual loss in the left eye 1 month previously. The patient smoked 10 cigarettes a day and was otherwise well. His vision was 6/6 in the right and NPL in the left. There was a left relative afferent pupillary defect, healthy anterior segments, and on fundoscopy the left disc was swollen with arterial attenuation and a central retinal embolus. A flourescein angiogram showed attenuation of arterial flow (Figure 1) with obstruction at the optic nerve, confirming the diagnosis of central retinal artery occlusion with ischaemic optic neuropathy.
Investigation with ultrasound B-scan, MRI, ECG, and Carotid Doppler scans was unremarkable as were haematological and biochemical investigations. Investigation for autoimmune conditions, prothrombotic diseases, and occult infections revealed no positive result. A mildly elevated homocysteine level of 20 μmol/l was detected (normal range 0–18 μmol/l).
Further investigation with transthoracic cardiac ultrasound with agitated saline contrast showed unprovoked right to left shunting across a patent foramen ovale. Further contrast injections with provocative manouvres (eg valsalva, sniff, and cough) increased the degree of right to left shunting (Figure 2). Aspirin (75 mg OD) with folic acid (300 mg OD) supplement was commenced and the patient listed for percutaneous device closure of the PFO.
Comment
CRAO is rare in patients below the age of 25 years and systemic diseases are usually causal. Common are; cardiac abnormalities, coagulopathies, collagen-vascular diseases, and oncological causes.1 Ocular causes in younger patients include optic nerve head drusen and peripapillary arterial loops.2 Long-term survival in patients with CRAO can be significantly reduced (5.5 years). The RECO study group found that 45% of CRAO patients under 45 years had cardiac abnormalities, of which 27% needed anticoagulation or cardiac surgery.3
PFO is the most common persistent abnormality of fetal origin, occurring in up to 29% of the normal adult population in autopsy studies.4 It has been reported in adult patients with embolic stroke over 55 years old, there is a higher prevelance of PFO (40%) than control subjects (10%. P<0.001).5 This association between PFO and systemic and cerebral embolism or ‘cryptogenic stroke’ has been consistently supported, particularly in young adults less than 55 years old.6 Aneyursmal atrial septum, large PFO size, and spontaneous passage of bubble contrast without provocative manoeuvres, as seen in our patient, have been cited as particular risk factors.7
Transcatheter PFO closure has a low complication rate (<1%) and was first reported to reduce the risk of recurrent cryptogenic strokes in-patients with PFO in 1992. A subsequent systematic review of percutaneous closure has shown it to have a protective effect on stroke or transient ischaemic attack recurrence compared to medical treatment (annualised incidence 1.9 vs 5.4%, relative risk 0.346, 95% CI 0.209–0.573; P<0.0001).8 Randomised control trials are currently assessing these therapeutic options more rigorously.9, 10
In this case a PFO with spontaneous right to left shunting was found following an ocular thromboembolic event. Closure of the PFO was performed to reduce the risk of stroke and bilateral loss of sight.
This case represents the importance of carrying out thorough investigation into potential embolic sources, particularly in young people, to determine the potential for treatment, which aims to reduce the risk of further embolism.
References
Duker JS, Yanoff M . Ophthalmology, 2nd ed. Mosby Inc., Philadelphia, 2002.
Newsom RS, Trew DR, Leonard TJ . Bilateral buried optic nerve drusen presenting with central retinal artery occlusion at high altitude. Eye 1995; 9 (Part 6): 806–808.
Sharma S, Sharma SM, Cruess AF, Brown GC . Transthoracic echocardiography in young patients with acute retinal arterial obstruction. RECO Study Group. Retinal Emboli of Cardiac Origin Group. Can J Ophthalmol 1997; 32 (1): 38–41.
Penther P . Patent foramen ovale: an anatomical study. Apropos of 500 consecutive autopsies. Arch Mal Coeur Vaiss 1994; 87 (1): 15–21.
Lechat P, Mas JL, Lascault G, Loron P, Theard M, Klimczac M et al. Prevalence of a patent foramen ovale in patients with stroke. N Eng J Med 1988; 318: 1148–1152.
Overell JR, Bone I, Lees KR . Interatrial septal abnormalities and stroke. A meta-analysis of case–control studies. Neurology 2000; 46: 1301–1305.
De Castro S, Cartoni D, Fiorelli M, Rasura M, Anzini A, Zanette EM et al.Morphological and functional characteristics of patent foramen ovale and their embolic implications. Stroke 2000; 31: 2407–2413.
Landzberg MJ, Khairy P . Indications for the closure of Patent Foramen Ovale. Heart 2004; 90: 219–224.
Furlan AJ . Patent foramen ovale and recurrent stroke: closure is the best option: yes. Stroke 2004; 35: 803–804.
Tong DC, Becker KJ . Patent Foramen Ovale and recurrent stroke: closure is the best option: no. Stroke 2004; 35: 804–805.
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Clifford, L., Sievers, R., Salmon, A. et al. Central retinal artery occlusion: association with patent foramen ovale. Eye 20, 736–738 (2006). https://doi.org/10.1038/sj.eye.6701983
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DOI: https://doi.org/10.1038/sj.eye.6701983
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