Sir,

I read with interest the article entitled ‘Cataract surgery after intra-vitreal injection of triamcinalone acetonide’ by Jonas et al.1 They have concluded that cataract surgery following intra-vitreal injection of triamcinalone is safe. This conclusion is based on a very small sample size of 22 cases. The posterior capsular rupture rate was calculated to be 4.5% based on one patient. I would expect the confidence interval to be large. The incidences of posterior capsular rupture in various reports have ranged between 1 and 4.8%. It is, therefore, difficult to draw any conclusions.

Secondary cataract was seen in one patient. A mean follow-up of 3.76 + 4.99 months is too short a period to reveal the true posterior capsular opacification rate.

Furthermore, with a reported incidence of postoperative endophthalmitis ranging between 0.04 and 0.2%, it is impossible to make any comments on the endophthalmitis rate based on a sample of 22 cases.

I feel that the conclusions have been overstated.