Sir,
I thank M Coluzzi et al for their interest in my letter published in 2003 on traditional behavioural practices and exchange of saliva among sub-Saharan African populations. The comments by M Coluzzi et al on my letter highlight a potentially important behavioural practice associated with human herpesvirus 8 (HHV-8) transmission; the use of saliva to soothe blood-sucking arthropod bites. As mentioned in my letter, I found some evidence of this practice in reviewing ethnographic material from the Human Relations Area Files (HRAF). However, neither the extent nor frequency of saliva-associated behavioural practices, including those highlighted by Coluzzi et al, has been investigated among sub-Saharan African populations. The HRAF files present only descriptive, ethnographic data. Scientifically oriented epidemio-logical studies need to be developed to better characterise the frequency and distribution of saliva-associated behavioural practices and evaluate the potential association between these practices and risk of infection with HHV-8.
The ‘promoter arthropod’ hypothesis raised by Coluzzi et al (2002) concerning the use of saliva to soothe blood-sucking arthropod bites merits further investigation and may pertain to transmission of other viruses in addition to HHV-8. In their letter, Coluzzi et al discuss ecological data from a previous study Coluzzi et al (2003), suggesting a relationship between larviciding campaigns and decreased population HHV-8 seroprevalence in Sardinia. Although this ecological level data is intriguing, the association may be confounded by other time-dependent environmental or behavioural factors, and individual level studies are needed to test this hypothesis. In addition, in light of widespread infection with HHV-8 in diverse sub-Saharan African environments, ecological level analysis may be less informative in this context. Studies that assess the frequency of behavioural practices associated with saliva including treatment of insect bites and exposures to proposed environmental risk factors (e.g. the density of ‘promoter arthropods’) at the individual level are needed.
Change history
16 November 2011
This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication
References
Coluzzi M, Calabro ML, Manno D, Chieco-Bianchi L, Schulz TF, Ascoli V (2003) Reduced seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV), human herpesvirus 8 (HHV-8), related to suppression of Anopheles density in Italy. Med Vet Entomol 17: 461–464
Coluzzi M, Manno D, Guzzinati S, Tognazzo S, Zmbon P, Arca B, Costantini C, Ascoli V (2002) The bloodsucking arthropod bite as possible cofactor in the transmission of human herpesvirus-8 infection and in the expression of Kaposi's sarcoma disease. Parasitologia 44: 123–129
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
About this article
Cite this article
Wojcicki, J. Reply: HHV-8 transmission via saliva to soothe blood-sucking arthropod bites. Br J Cancer 91, 999 (2004). https://doi.org/10.1038/sj.bjc.6602087
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bjc.6602087