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Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

Genes & Immunity volume 8, pages 181–192 (2007)Cite this article

Abstract

The immunobiology of hepatitis C virus (HCV) is significantly influenced by the host immune response to the virus, especially by virus-specific T-cell responses. Virus-specific T cells are restricted by human leucocyte antigen class I and II molecules. Of note, associations between these polymorphic loci and outcome and course of HCV infection have been reported in large and well-documented cohorts. This review will briefly summarize these studies and focus especially on the immunological and virological basis for the reported associations. The outcome and course of HCV infection is most likely determined by a complex interplay of genetic, immunological and virological factors. A better understanding of these host–virus interactions is essential not only to gain better insights into the mechanisms of viral clearance and persistence but also for the development of new antiviral vaccine strategies.

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Acknowledgements

We thank all members of our laboratory for excellent work and helpful discussion as well as Dr Jörg Timm for helpful discussions and critically reading the manuscript. CN-H is supported by the Kompetenznetz Hepatitis (HepNet, BMWF), RT is supported by the Deutsche Forschungsgemeinschaft (TH 719/2-2 and 2-3, Emmy Noether Programm; SFB 620), and the Wilhelm Sander Foundation.

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  1. Department of Medicine II, University of Freiburg, Freiburg, Germany

    C Neumann-Haefelin & R Thimme

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  1. C Neumann-Haefelin
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  2. R Thimme
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Correspondence to R Thimme.

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Neumann-Haefelin, C., Thimme, R. Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection. Genes Immun 8, 181–192 (2007). https://doi.org/10.1038/sj.gene.6364368

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  • DOI: https://doi.org/10.1038/sj.gene.6364368

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