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cPSA and fPSA elimination in African-American men

Prostate Cancer and Prostatic Diseases volume 6, pages 163–168 (2003)Cite this article

Abstract

In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple first-order exponential elimination kinetic, with a half-life of 44.6 h. fPSA followed a two-compartment elimination with an α-phase elimination of 0.50 h and a β-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races.

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References

  1. Stamey TA et al. Prostate specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 1987; 317: 909–916.

    Article  CAS  PubMed  Google Scholar 

  2. Brawley OW, Knopf K, Merrill R . The epidemiology of prostate cancer Part I: descriptive epidemiology. Sem Urol Oncol 1998; 16: 187–192.

    CAS  Google Scholar 

  3. Miller BA et al. Cancer Statistics Review: 1973–1989. National Cancer Institute: Bethesda, MA, 1992.

    Google Scholar 

  4. Smith DS, Bullock AD, Catalona WJ, Herschman JD . Racial differences in a prostate cancer screening study. J Urol 1996; 156: 1366–1369.

    Article  CAS  PubMed  Google Scholar 

  5. Brawley OW . Prostate cancer and Black men. Semin Urol Oncol 1998; 16: 184–186.

    CAS  PubMed  Google Scholar 

  6. Abdalla I, Ray P, Vijayakumar S . Race and serum prostate specific antigen levels: current status and future directions. Semin Urol Oncol 1998; 16: 207–213.

    CAS  PubMed  Google Scholar 

  7. Pettaway CA et al. Prostate specific antigen and pathological features of prostate cancer in Black and White patients: a comparative study based on radical prostatectomy specimens. J Urol 1998; 160: 437–442.

    Article  CAS  PubMed  Google Scholar 

  8. Moul JW et al. Prostate-specific antigen values at the time of prostate cancer diagnosis in African-American men. JAMA 1995; 274: 1277–1281.

    Article  CAS  PubMed  Google Scholar 

  9. Vijayakumar S et al. Racial differences in prostate-specific antigen levels in patients with local-regional prostate cancer. Cancer Epidemiol, Biomarkers Preven 1992; 1: 541–545.

    CAS  Google Scholar 

  10. Eastham JA et al. Racial variation in prostate specific antigen in a large cohort of men without prostate cancer. J Louisiana State Med Soc 2001; 153: 184–189.

    CAS  Google Scholar 

  11. DeAntoni EP et al. Age- and race-specific reference ranges for prostate specific antigen from a large community-based study. Urolog 1996; 48: 234–239.

    Article  CAS  Google Scholar 

  12. Morgan TO et al. Age-specific reference ranges for serum prostate-specific antigen in Black men. N Engl J Med 1996; 335: 304–310.

    Article  CAS  PubMed  Google Scholar 

  13. Montie JE, Pienta KJ . A unifying model to explain the increased incidence and higher mortality of prostate cancer in Black men. Urology 1999; 53: 1073–1076.

    Article  CAS  PubMed  Google Scholar 

  14. Sakr WA, Grignon DJ, Haas GP . Pathology of pre-malignant lesions and carcinoma of the prostate in African-American men. Semin Urol Oncol 1998; 16: 214–220.

    CAS  PubMed  Google Scholar 

  15. Allard WJ, Zhou Z, Yeung KK . Novel immunoassay for the measurement of complexed prostate specific antigen in serum. Clini Chem 1998; 44: 1216–1223.

    CAS  Google Scholar 

  16. Brandle E, Hautmann O, Bachen M . Serum half-life determination of free and total prostate-specific antigen following radical prostatectomy—a critical assessment. Urology 1999; 53: 722–730.

    Article  CAS  PubMed  Google Scholar 

  17. Agha AH, Schechter E, Roy J, Culkin DJ . Prostate specific antigen is metabolized in the liver. J Urol 1996; 155: 1332–1335.

    Article  CAS  PubMed  Google Scholar 

  18. Richardson TD, Wojno KJ, Liang LW . Half-life determination of serum free prostate-specific antigen following radical retropubic prostatectomy. Urology 1996; 48: 40–44.

    Article  CAS  PubMed  Google Scholar 

  19. Lilja H, Haese A, Bjork T . Significance and metabolism of complexed and noncomplexed prostate specific antigen forms, and human glandular Kallikrein 2 in clinically localized cancer before and after radical prostatectomy. J Urol 1999; 162: 2029–2035.

    Article  CAS  PubMed  Google Scholar 

  20. Semjonow A, Hamm M, Rathert P . Elimination kinetics of prostate-specific antigen serum and urine. Int J Biol Markers 1994; 9: 15–20.

    Article  CAS  PubMed  Google Scholar 

  21. Perlmutter DH et al. Identification of a serpine enzyme complex receptor on human hepatoma cells and human monocytes. Proc Natl Acad Sci USA 1990; 87: 3753–3757.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Mast AE, Enghild JJ, Pizzo SV, Salvesen G . Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha1-proteinase inhibitor, alpha1-antichymotrypsin, antithrombin III, alpha2-antiplasmin, angiotensinogen, and ovalbumin. Biochemistry 1991; 30: 1723–1730.

    Article  CAS  PubMed  Google Scholar 

  23. Stephan C et al. Elimination of serum complexed prostate specific antigen after radical retropubic prostatectomy. Clin Chem Lab Med 2000; 38: 309–311.

    Article  CAS  PubMed  Google Scholar 

  24. Stephan C et al. ACT-PSA and complexed PSA elimination kinetics in serum after radical retropubic prostatectomy: proof of new complex forming of PSA after release into circulation. Urology 2000; 55: 560–563.

    Article  CAS  PubMed  Google Scholar 

  25. Bjork T, Ljungberg B, Pironen T . Rapid exponential elimination of free prostate-specific antigen contrasts the slow, capacity-limited elimination of PSA complexed to alpha1-antichymotrypsin from serum. Urology 1998; 51: 57–62.

    Article  CAS  PubMed  Google Scholar 

  26. Haab F, Meulemans A, Bocon-Gibod L . Clearance of serum PSA after open surgery for benign prostatic hypertrophy, radical cystectomy, and radical prostatectomy. The Prostate 1995; 26: 334–338.

    Article  CAS  PubMed  Google Scholar 

  27. Oesterling JE, Chan DW, Epstein JI . Prostate specific antigen in the preoperative and postoperative evaluation of localized prostatic cancer treated with radical prostatectomy. J Urol 1998; 139: 766–772.

    Article  Google Scholar 

  28. Partin AW, Piantadosi S, Subong ENP . Clearance rate of serum free and total PSA following radical retropubic prostatectomy. The Prostate 1996; 7(Suppl): 35–39.

    Article  CAS  PubMed  Google Scholar 

  29. Colar CB, Coptcoat MJ, Mulvin D . The release of free prostate specific antigen into the circulation during transurethral resection of the prostate: kinetics and interaction with serum protease inhibitors. Br J Urol 1998; 81: 105–108.

    Article  Google Scholar 

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Acknowledgements

We thank Dr Gary Knott for his help with utilization of the MLAB software.

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Authors and Affiliations

  1. Department of Urology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

    B J Martin, M Ward, M Kokatnur, D Mercante, D Lifsey & W Rayford

  2. Bayer Corporation, Tarrytown, New York, USA

    C Cheli

  3. Tulane University, New Orleans, Louisiana, USA

    R Davis

Authors
  1. B J Martin
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  2. C Cheli
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  3. R Davis
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  4. M Ward
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  6. D Mercante
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  7. D Lifsey
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  8. W Rayford
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Correspondence to W Rayford.

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Martin, B., Cheli, C., Davis, R. et al. cPSA and fPSA elimination in African-American men. Prostate Cancer Prostatic Dis 6, 163–168 (2003). https://doi.org/10.1038/sj.pcan.4500649

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  • DOI: https://doi.org/10.1038/sj.pcan.4500649

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