Abstract
Monocular deprivation (MD) has much more rapid and severe effects on the ocular dominance of neurons in the primary visual cortex (V1) than does binocular deprivation1. This finding underlies the widely held hypothesis that the developmental plasticity of ocular dominance reflects competitive interactions for synaptic space between inputs from the two eyes2. According to this view, the relative levels of evoked activity in afferents representing the two eyes determine functional changes in response to altered visual experience. However, if the deprived eye of a monocularly deprived kitten is simply reopened, there is substantial physiological and behavioural recovery, leading to the suggestion that absolute activity levels, or some other non-competitive mechanisms, determine the degree of recovery from MD3,4,5,6,7. Here we provide evidence that correlated binocular input is essential for such recovery. Recovery is far less complete if the two eyes are misaligned after a period of MD. This is a powerful demonstration of the importance of cooperative, associative mechanisms in the developing visual cortex.
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Acknowledgements
We thank M. Bear and H. Shouval for their helpful discussions, and I. Kehrer and M. Jones for technical assistance. This work was supported by the Wellcome Trust (P.C.K.), the Medical Research Council (C.B., F.S., B.A.), Max-Planck-Gesellschaft (T.B., F.S.), the Canadian Institutes of Health Research (D.E.M.) and the Oxford McDonnell Centre for Cognitive Neuroscience (C.B., B.A.).
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Kind, P., Mitchell, D., Ahmed, B. et al. Correlated binocular activity guides recovery from monocular deprivation. Nature 416, 430–433 (2002). https://doi.org/10.1038/416430a
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DOI: https://doi.org/10.1038/416430a
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