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The association of DUSP6 gene with schizophrenia and bipolar disorder: its possible role in the development of bipolar disorder

Molecular Psychiatry volume 11, pages 425–426 (2006)Cite this article

Dual specificity phosphatase 6 gene (DUSP6) is a candidate for bipolar disorder and schizophrenia due to its positional and functional significance. DUSP6 gene is located on chromosome 12q22–q23,1 a region frequently implicated in linkage studies of major psychiatric disorders.2, 3 Also known as mitogen-activated protein kinase phosphatase 3 (MKP3), DUSP6 additionally plays a key role in regulating extracellular signal-regulated kinase (ERK) 1/2 pathway which is implicated in pathophysiology of major psychiatric disorders.4, 5

Although Toyota et al. (2000) reported a lack of association between Japanese bipolar patients and T/G polymorphism (rs2279574, Leu114Val) in DUSP6 gene,6 a number of recent findings strongly suggests the involvement of DUSP6 in mediating psychiatric manifestations. For example, DUSP6 mRNA increases after electroconvulsive seizure in rat brain.7 Also, atypical antipsychotics and mood stabilizers stimulate ERK pathway involved in synaptic plasticity and long-term potentiation.8, 9 Moreover, MAPK cascade that includes DUSP6 activation is essential for the regulation of circadian rhythm genes, which is another possible etiology of bipolar disorder.10 Unfortunately, despite its pathophysiological significance, available data on the genetic association of DUSP6 gene are limited. We thereby examined its association with the two major psychiatric disorders, namely bipolar disorder and schizophrenia, in the Korean population.

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Acknowledgements

This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002).

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Authors and Affiliations

  1. Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea

    K Y Lee, Y M Ahn & Y S Kim

  2. Department of Psychiatry and Behavioral Science and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Y M Ahn & Y S Kim

  3. Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea

    Y M Ahn, J S Chang & Y S Kim

  4. Department of Neuropsychiatry, Eulji University School of Medicine, Daegeon, Republic of Korea

    E-J Joo

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  1. K Y Lee
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Lee, K., Ahn, Y., Joo, EJ. et al. The association of DUSP6 gene with schizophrenia and bipolar disorder: its possible role in the development of bipolar disorder. Mol Psychiatry 11, 425–426 (2006). https://doi.org/10.1038/sj.mp.4001807

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