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Absence of psychosis may influence linkage results for bipolar disorder

Molecular Psychiatry volume 10, pages 235–237 (2005)Cite this article

SIR—Dissection of the clinical phenotype into more homogeneous subtypes can enhance the prospects of linkage analysis. In this study, we report linkage results for bipolar disorder (BP) without psychosis (non-psychotic BP). To our knowledge, there are no published genome-wide linkage studies that focus on nonpsychotic BP.

We have previously reported that linkage analysis of BP with psychosis (psychotic BP) suggests novel susceptibility loci for BP, and that some of the linkage signals are also implicated in schizophrenia.1 Here we hypothesize that nonpsychotic BP might produce linkage findings that differ from those reported for psychotic BP.

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Authors and Affiliations

  1. Columbia Genome Center and Department of Psychiatry, Columbia University, New York, NY, USA

    N Park, R Cheng, S H Juo, J Liu, J E Loth, J Endicott, T C Gilliam & M Baron

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  1. N Park
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  2. R Cheng
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  3. S H Juo
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  4. J Liu
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  5. J E Loth
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  6. J Endicott
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  7. T C Gilliam
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  8. M Baron
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Correspondence to M Baron.

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Park, N., Cheng, R., Juo, S. et al. Absence of psychosis may influence linkage results for bipolar disorder. Mol Psychiatry 10, 235–237 (2005). https://doi.org/10.1038/sj.mp.4001623

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