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  • Scientific Correspondence
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Strauch et al reply

Molecular Psychiatry volume 5, pages 126–127 (2000)Cite this article

SIR – Dr Paterson raises a number of important points regarding parental-origin (imprinting) effects in linkage analysis. He draws attention to new methods which take possible imprinting effects into account; methods which were not available to investigators until very recently.

There is a general agreement that linkage reports in complex traits need replication to become credible,1 notwithstanding that replication in these situations is not without problems.2 In our analysis of chromosome 18 linkage data in bipolar disorder we tried to replicate the results of earlier investigators3, 4 by applying methods that were previously shown to provide evidence for linkage. We agree that the classification of a particular pedigree into ‘paternal’ or ‘maternal’ trait transmission can be arbitrary and that this strategy, therefore, may not be the most appropriate to account for possible imprinting effects. This strategy simply aims to select for families in which it is more likely that a disease allele at a locus subject to imprinting shows an effect in comparison to a randomly selected family.

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References

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Authors and Affiliations

  1. Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Sigmund-Freud-Str 25, Bonn, 53105, Germany

    K Strauch, R Fimmers, T F Wienker & M P Baur

  2. Institute of Human Genetics, University of Bonn, Wilhelmstr 31, Bonn, 53111, Germany

    S Cichon, P Propping & M M Nöthen

Authors
  1. K Strauch
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  2. R Fimmers
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  3. T F Wienker
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  4. M P Baur
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  5. S Cichon
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  6. P Propping
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  7. M M Nöthen
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Correspondence to M M Nöthen.

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Strauch, K., Fimmers, R., Wienker, T. et al. Strauch et al reply. Mol Psychiatry 5, 126–127 (2000). https://doi.org/10.1038/sj.mp.4000668

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