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Apoptosis

DNA destroyers

Proteins with quite mundane functions in healthy cells often behave very differently during cell suicide. One protein normally involved in copying mitochondrial DNA actually degrades nuclear DNA in dying cells.

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References

  1. Wyllie, A. H. Nature 284, 555–556 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Nagata, S. Exp. Cell Res. 256, 12–18 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Wu, Y. C., Stanfield, G. M. & Horvitz, H. R. Genes Dev. 14, 536–548 (2000).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Li, L. Y., Luo, X. & Wang, X. Nature 412, 95–99 (2001).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Parrish, J. et al. Nature 412, 90–94 (2001).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Cote, J. & Ruiz-Carillo, A. Science 261, 765–769 (1993).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Lorenzo, H. K., Susin, S. A., Penninger, J. & Kroemer, G. Cell Death Differ. 6, 516–524 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. Chen, F. et al. Science 287, 1485–1489 (2000).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Hengartner, M. O. Nature 407, 770–776 (2000).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Michael O. Hengartner.

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Hengartner, M. DNA destroyers. Nature 412, 27–29 (2001). https://doi.org/10.1038/35083663

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