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Chromatic sensitivity of ganglion cells in the peripheral primate retina

Nature volume 410, pages 933–936 (2001)Cite this article

Abstract

Visual abilities change over the visual field. For example, our ability to detect movement is better in peripheral vision than in foveal vision, but colour discrimination is markedly worse1,2. The deterioration of colour vision has been attributed to reduced colour specificity in cells of the midget, parvocellular (PC) visual pathway in the peripheral retina3,4,5. We have measured the colour specificity (red–green chromatic modulation sensitivity) of PC cells at eccentricities between 20 and 50 degrees in the macaque retina. Here we show that most peripheral PC cells have red–green modulation sensitivity close to that of foveal PC cells. This result is incompatible with the view that PC pathway cells in peripheral retina make indiscriminate connections (‘random wiring’) with retinal circuits devoted to different spectral types of cone photoreceptors4,6,7. We show that selective cone connections can be maintained by dendritic field anisotropy, consistent with the morphology of PC cell dendritic fields in peripheral retina8,9. Our results also imply that postretinal mechanisms contribute to the psychophysically demonstrated deterioration of colour discrimination in the peripheral visual field.

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Figure 1: Morphology of PC cells.
Figure 2: Modulation sensitivity.
Figure 3: PC cell dendritic tree9 on a fragment of macaque cone mosaic25 scaled to local cone density and gaussian filtered.
Figure 4: Simulation of cone inputs to peripheral PC cells.

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Acknowledgements

We thank B. Roser and B. Grünert for technical assistance; B. Dreher, U. Grünert, P. Lennie and H. Wässle for helpful discussions and suggestions; A. Goodchild and K. Ghosh for Neurobiotin labelling of ganglion cells; and A. Roorda for cone matrix data.

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Authors and Affiliations

  1. Department of Physiology and Institute for Biomedical Research, University of Sydney, 2006, NSW, Australia

    Paul R. Martin, Andrew J. R. White & Samuel G. Solomon

  2. Neurobiology group, Max-Planck-Institute for Biophysical Chemistry, Göttingen, D37077, Germany

    Barry B. Lee & Lukas Rüttiger

  3. State College of Optometry, SUNY, New York, 10036-8003, New York, USA

    Barry B. Lee

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  1. Paul R. Martin
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Correspondence to Paul R. Martin.

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Martin, P., Lee, B., White, A. et al. Chromatic sensitivity of ganglion cells in the peripheral primate retina. Nature 410, 933–936 (2001). https://doi.org/10.1038/35073587

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