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Prions

The shape of a species barrier

Intriguing in vitro results highlight the possibility that conformational differences between prion proteins with the same sequence contribute to the barrier that limits prion propagation between species.

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Figure 1: Model showing the involvement of fibre conformations in the species barrier between the yeasts Candida albicans and Saccharomyces cerevisiae .

References

  1. Prusiner, S. B. Proc. Natl Acad. Sci. USA 95, 13363–13383 (1998).

    Article  ADS  CAS  Google Scholar 

  2. Caughey, B. & Chesebro, B. Trends Cell Biol. 7, 56–62 (1997).

    Article  CAS  Google Scholar 

  3. Chien, P. & Weissman, J. S. Nature 410, 223–227 (2001).

    Article  ADS  CAS  Google Scholar 

  4. Wickner, R. B. Science 264, 566–569 (1994).

    Article  ADS  CAS  Google Scholar 

  5. Cox, B. S., Tuite, M. F. & McLaughlin, C. S. Yeast 4, 159–178 (1988).

    Article  CAS  Google Scholar 

  6. Derkatch, I. L., Chernoff, Y. O., Kushnirov, V. V., Inge-Vechtomov, S. G. & Liebman, S. W. Genetics 144, 1375–1386 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Zhou, P. et al. EMBO J. 18, 1182–1191 (1999).

    Article  CAS  Google Scholar 

  8. Glover, J. R. et al. Cell 89, 811–819 (1997).

    Article  CAS  Google Scholar 

  9. King, C. Y. et al. Proc. Natl Acad. Sci. USA 94, 6618–6622 (1997).

    Article  ADS  CAS  Google Scholar 

  10. DePace, A. H., Santoso, A., Hillner, P. & Weissman, J. S. Cell 93, 1241–1252 (1998).

    Article  CAS  Google Scholar 

  11. Santoso, A., Chien, P., Osherovich, L. Z. & Weissman, J. S. Cell 100, 277–288 (2000).

    Article  CAS  Google Scholar 

  12. Kochneva-Pervukhova, N. V. et al. EMBO J. 17, 5805–5810 (1998).

    Article  CAS  Google Scholar 

  13. Liu, J. J. & Lindquist, S. Nature 400, 573–576 (1999).

    Article  ADS  CAS  Google Scholar 

  14. Chernoff, Y. O. et al. Mol. Microbiol. 35, 865–876 (2000).

    Article  CAS  Google Scholar 

  15. Kushnirov, V. V., Kochneva-Pervukhova, N. V., Chechenova, M. B., Frolova, N. S. & Ter-Avanesyan, M. D. EMBO J. 19, 324–331 (2000).

    Article  CAS  Google Scholar 

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Correspondence to Susan W. Liebman.

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Liebman, S. The shape of a species barrier. Nature 410, 161–162 (2001). https://doi.org/10.1038/35065778

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