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A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe

Nature volume 332, pages 509–514 (1988)Cite this article

Abstract

In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting its enzymatic activity. Inactivation of the ran1+ protein kinase is both necessary and sufficient to divert a vegetative cell from mitotic division to meiotic differentiation.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York, 11724, USA

    Maureen McLeod & David Beach

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  1. Maureen McLeod
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  2. David Beach
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McLeod, M., Beach, D. A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe. Nature 332, 509–514 (1988). https://doi.org/10.1038/332509a0

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