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Gene therapy in wound healing: present status and future directions

Gene Therapy volume 14, pages 1–10 (2007)Cite this article

Abstract

Gene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The realization that gene therapy applications were much vaster has opened up endless opportunities for therapeutic genetic manipulations, especially in the skin and external wounds. Cutaneous wound healing is a complicated, multistep process with numerous mediators that act in a network of activation and inhibition processes. Gene delivery in this environment poses a particular challenge. Numerous models of gene delivery have been developed, including naked DNA application, viral transfection, high-pressure injection, liposomal delivery, and more. Of the various methods for gene transfer, cationic cholesterol-containing liposomal constructs are emerging as a method with great potential for non-viral gene transfer in the wound. This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field.

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Acknowledgements

We thank Liz Cook, Eileen Figueroa, and Steve Schuenke, Publications Office, Department of Surgery, The University of Texas Medical Branch, Galveston Texas, for their help in the preparation of this manuscript. We acknowledge the Postdoctoral Training in Trauma and Burns (T32-GM08256) and the Clayton Foundation for Research.

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  1. L K Branski and C T Pereira: These two authors contributed equally to the present work.

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  1. Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA

    L K Branski, C T Pereira, D N Herndon & M G Jeschke

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Branski, L., Pereira, C., Herndon, D. et al. Gene therapy in wound healing: present status and future directions. Gene Ther 14, 1–10 (2007). https://doi.org/10.1038/sj.gt.3302837

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