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X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele

Nature volume 315, pages 226–227 (1985)Cite this article

A Corrigendum to this article was published on 01 August 1985

Abstract

In the human there is an X-linked gene affecting steroid sulphatase (STS) activity which, when deficient, is associated with X-linked congenital ichthyosis1,2. The gene (STS) is located on the distal tip of the short arm3–6 and is only partially inactivated when it is on the inactive X-chromosome7–10. In the mouse, the genetics of STS are not clear; the results of one study using XX:X0 oocyte comparisons indicated X-linkage11, but three other studies using STS variants have produced segregation data compatible with autosomal linkage of murine STS12–14. Here we present the results of STS assays of crosses of deficient C3H/An male mice12 to normal X0 animals which demonstrate X-linkage of STS in the mouse and indirectly indicate the existence of a functional STS allele on the Y-chromosome which undergoes obligatory recombination during meiosis with the X-linked allele.

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References

  1. Jobsis, A. G. et al. Ned. Tijdschr. Geneesk. 120, 1980 (1976).

    Google Scholar 

  2. Shapiro, L. J., Weiss, R., Webster, D. & France, J. T. Lancet i, 70–72 (1978).

    Article  Google Scholar 

  3. Tiepolo, L. et al. Hum. Genet. 54, 205–206 (1980).

    Article  CAS  Google Scholar 

  4. Muller, C. R. Westerveld, A., Migl, B., Franke, W. & Ropers, H. H. Hum. Genet. 54, 201–204 (1980).

    Article  CAS  Google Scholar 

  5. Mohandas, T., Shapiro, L. J., Sparkes, R. S. & Sparkes, M. C. Proc. natn. Acad. Sci. U.S.A. 76, 5779–5783 (1979).

    Article  ADS  CAS  Google Scholar 

  6. Mohandas, T., Sparkes, R. S., Hellkuhl, B., Grzeschik, K. H. & Shapiro, L. J. Proc. natn. Acad. Sci. U.S.A. 77, 6759–6763 (1980).

    Article  ADS  CAS  Google Scholar 

  7. Muller, C. R., Migl, B., Traupe, H. & Ropers, H. H. Hum. Genet. 54, 197–199 (1980).

    Article  CAS  Google Scholar 

  8. Chance, P. F. & Gartler, S. M. Am. J. Hum. Genet. 35, 234–240 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Ropers, H. H. et al. Hum. Genet. 57, 354–356 (1981).

    Article  CAS  Google Scholar 

  10. Migeon, B. R. et al. Nature 299, 838–840 (1982).

    Article  ADS  CAS  Google Scholar 

  11. Gartler, S. M. & Rivest, M. Genetics 103, 137–141 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Balazs, I., Purrello, M., Rocchi, M. & Siniscalco, M. Cytogenet. Cell Genet. 32, 251 (1982).

    Google Scholar 

  13. Erickson, R. P., Harper, K. & Kramer, J. M. Genetics 105, 181–189 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Keinanen, B. M., Nelson, K., Daniel, W. L. & Roque, J. M. Genetics 105, 191–206 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Solari, A. J. Int. Rev. Cytol. 38, 273–317 (1974).

    Article  ADS  CAS  Google Scholar 

  16. Ferguson-Smith, M. A. Lancet ii, 475–476 (1966).

    Article  Google Scholar 

  17. Burgoyne, P. S. Hum. Genet. 61, 85–90 (1982).

    Article  CAS  Google Scholar 

  18. Polani, P. E. Hum. Genet. 60, 207–211 (1982).

    Article  CAS  Google Scholar 

  19. Cattanach, B. M., Pollard, C. E. & Hawkes, S. G. Cytogenetics 10, 318–337 (1971).

    Article  CAS  Google Scholar 

  20. Singh, L. & Jones, K. W. Cell 28, 205–216 (1982).

    Article  CAS  Google Scholar 

  21. Evans, E. P., Burtenshaw, M. D. & Cattanach, B. Nature 300, 443–445 (1983).

    Article  ADS  Google Scholar 

  22. Ashley, T. Hum. Genet. 67, 372–377 (1984).

    Article  CAS  Google Scholar 

  23. Goodfellow, P. et al. Nature 302, 346–349 (1983).

    Article  ADS  CAS  Google Scholar 

  24. Goodfellow, P. N. & Tippett, P. Nature 289, 404–405 (1981).

    Article  ADS  CAS  Google Scholar 

  25. de la Chapelle, A. Hum. Genet. 58, 105–116 (1981).

    Article  CAS  Google Scholar 

  26. Evans, H. J., Buckton, K. E., Spowart, G. & Carothers, A. D. Hum. Genet. 49, 11–31 (1979).

    CAS  PubMed  Google Scholar 

  27. Pierella, P., Craig, I., Bobrow, M. & de la Chapelle, A. Hum. Genet. 59, 87–88 (1981).

    Article  CAS  Google Scholar 

  28. Wieacker, P., Voiculescu, J., Muller, C. R. & Ropers, H. H. Cytogenet. Cell Genet. 35, 72–74 (1983).

    Article  CAS  Google Scholar 

  29. de la Chapelle, A. Tippett, P. A., Wetterstrand, G. & Page, D. Nature 307, 170–171 (1984).

    Article  ADS  CAS  Google Scholar 

  30. Guellaen, G. et al. Nature 307, 172–173 (1984).

    Article  ADS  CAS  Google Scholar 

  31. Crocker, M. & Craig, I. Nature 303, 721–722 (1983).

    Article  ADS  CAS  Google Scholar 

  32. Shapiro, L. J., Cousins, L., Fluharty, A. L., Stevens, R. L. & Kihara, H. Pediat. Res. 11, 894–897 (1977).

    Article  CAS  Google Scholar 

  33. McNaught, R. W. & France, J. T. J. Steroid Biochem. 13, 363–373 (1980).

    Article  CAS  Google Scholar 

  34. Lowry, O. H., Rosebrough, N. J., Lewis Farr, A. & Randall, R. J. J. biol. Chem. 193, 265–275 (1951).

    CAS  PubMed  Google Scholar 

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Author notes

  1. Marcello Siniscalco: Memorial Sloan-Kettering Cancer Center and Department of Cell Biology and Genetics, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA

Authors and Affiliations

  1. The Center for Inherited Diseases, Departments of Medicine and Genetics, SK-50, University of Washington, Seattle, Washington, 98195, USA

    Elisabeth Keitges, Martha Rivest, Marcello Siniscalco & Stanley M. Gartler

Authors
  1. Elisabeth Keitges
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  2. Martha Rivest
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  3. Marcello Siniscalco
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  4. Stanley M. Gartler
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Keitges, E., Rivest, M., Siniscalco, M. et al. X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele. Nature 315, 226–227 (1985). https://doi.org/10.1038/315226a0

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