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Polyoma virus DNA replication requires an enhancer

Nature volume 312, pages 242–246 (1984)Cite this article

Abstract

Sequences which activate polyoma virus DNA replication are located within a region that also includes the transcriptional enhancer. We demonstrate a cis involvement of enhancers in DNA replication by showing that this region can be replaced by other enhancers, in a position- and orientation-independent manner, and that an immunoglobulin gene enhancer confers tissue-specific replicatory ability.

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Author information

Author notes

  1. Jean de Villiers

    Present address: Genetics Institute, 225 Longwood Avenue, Boston, Massuchusetts, 02115, USA

  2. Chiara Tyndall

    Present address: CSIRO Genetics Research Laboratories, North Ryde, New South Wales, Australia

  3. Steven Lupton

    Present address: Department of Microbiology, State University of New York, Stony Brook, 11794, USA

Authors and Affiliations

  1. Institut für Molekularbiologie II der Universität Zürich, Honggerberg, CH 8093, Switzerland

    Jean de Villiers & Walter Schaffner

  2. ICRF Laboratories, Lincoln's Inn Fields, London, WC2A 3PX, UK

    Chiara Tyndall & Steven Lupton

  3. Genetics Institute, 225 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Robert Kamen

Authors
  1. Jean de Villiers
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  2. Walter Schaffner
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  3. Chiara Tyndall
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  4. Steven Lupton
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  5. Robert Kamen
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de Villiers, J., Schaffner, W., Tyndall, C. et al. Polyoma virus DNA replication requires an enhancer. Nature 312, 242–246 (1984). https://doi.org/10.1038/312242a0

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