Abstract
Arginine-vasopressin (AVP) is a neurohypophysial nonapeptide with antidiuretic activity involved in the control of blood volume and plasma osmolality1. Recently, by immunological methods, the presence of AVP has been demonstrated in extrahypothalamic areas of the brain, in the spinal cord2 and in the ovary3, testis4 and adrenal gland5. The Brattleboro rat is regarded as having an autosomal recessively inherited lack of neurohypophysial vasopressin6 and its associated neurophysin7. Since its discovery over 20 years ago8 this animal has been widely used in studies on the physiological role of vasopressin. We have recently investigated the presence of immunoreactive vasopressin and the related nonapeptide oxytocin in the adrenal glands of the human, rat and cow, and report here the isolation from the Brattleboro rat adrenal of material with similar immunological, physical and biological properties to synthetic vasopressin.
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Nussey, S., Ang, V., Jenkins, J. et al. Brattleboro rat adrenal contains vasopressin. Nature 310, 64–66 (1984). https://doi.org/10.1038/310064a0
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DOI: https://doi.org/10.1038/310064a0
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